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Cell host & microbe
Oct 18, 2012;12 (4): 496-508.

Intestinal commensal microbes as immune modulators.

Ivaylo I Ivanov, Kenya Honda
Author Information
  1. Ivaylo I Ivanov: Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. ii2137@columbia.edu
PMID: 23084918 DOI: 10.1016/j.chom.2012.09.009

Abstract

Commensal bacteria are necessary for the development and maintenance of a healthy immune system. Harnessing the ability of microbiota to affect host immunity is considered an important therapeutic strategy for many mucosal and nonmucosal immune-related conditions, such as inflammatory bowel diseases (IBDs), celiac disease, metabolic syndrome, diabetes, and microbial infections. In addition to well-established immunostimulatory effects of the microbiota, the presence of individual mutualistic commensal bacteria with immunomodulatory effects has been described. These organisms are permanent members of the commensal microbiota and affect host immune homeostasis in specific ways. Identification of individual examples of such immunomodulatory commensals and understanding their mechanisms of interaction with the host will be invaluable in designing therapeutic strategies to reverse intestinal dysbiosis and recover immunological homeostasis.

References

  1. Science. 2005 Mar 25;307(5717):1955-9 [PMID: 15790854]
  2. Cell Host Microbe. 2011 Sep 15;10(3):260-72 [PMID: 21925113]
  3. Cell. 2011 May 27;145(5):745-57 [PMID: 21565393]
  4. Nature. 2008 May 8;453(7192):236-40 [PMID: 18368049]
  5. Gastroenterology. 2009 May;136(6):1979-88 [PMID: 19457422]
  6. Nature. 2012 Feb 01;482(7384):179-85 [PMID: 22297845]
  7. Science. 2010 Aug 13;329(5993):849-53 [PMID: 20705860]
  8. Immunity. 2008 Apr;28(4):546-58 [PMID: 18387831]
  9. Science. 2010 Apr 9;328(5975):228-31 [PMID: 20203013]
  10. Lobund reports. 1946 Nov;(1):1-84 [PMID: 20247584]
  11. Mucosal Immunol. 2011 Jan;4(1):4-7 [PMID: 21150894]
  12. J Immunol. 2011 Jul 15;187(2):733-47 [PMID: 21666057]
  13. Nat Immunol. 2008 Jul;9(7):769-76 [PMID: 18516037]
  14. Nat Rev Immunol. 2010 Mar;10(3):159-69 [PMID: 20182457]
  15. Cell Host Microbe. 2008 Oct 16;4(4):337-49 [PMID: 18854238]
  16. Immunity. 2011 Nov 23;35(5):780-91 [PMID: 22018469]
  17. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15813-8 [PMID: 19805227]
  18. Immunity. 2009 Oct 16;31(4):677-89 [PMID: 19833089]
  19. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698-703 [PMID: 19234110]
  20. J Clin Invest. 2010 Dec;120(12):4445-52 [PMID: 21099114]
  21. Nat Rev Immunol. 2004 Jun;4(6):478-85 [PMID: 15173836]
  22. Nature. 2012 Jun 13;486(7402):207-14 [PMID: 22699609]
  23. Nat Rev Immunol. 2010 Oct;10(10):735-44 [PMID: 20865020]
  24. Immunity. 2012 Jul 27;37(1):171-86 [PMID: 22749822]
  25. Immunity. 2011 May 27;34(5):794-806 [PMID: 21596591]
  26. Nature. 2006 Dec 21;444(7122):1027-31 [PMID: 17183312]
  27. BMC Microbiol. 2012 Jun 06;12:95 [PMID: 22672413]
  28. Immunity. 2012 Jan 27;36(1):92-104 [PMID: 22177117]
  29. Cell. 2011 Oct 28;147(3):629-40 [PMID: 21999944]
  30. Cell. 2012 Mar 16;148(6):1258-70 [PMID: 22424233]
  31. Cell. 2007 Oct 5;131(1):33-45 [PMID: 17923086]
  32. Science. 2012 Aug 31;337(6098):1115-9 [PMID: 22837383]
  33. J Exp Med. 2012 Jul 30;209(8):1445-56 [PMID: 22826298]
  34. Nature. 2011 Sep 21;478(7368):250-4 [PMID: 21937990]
  35. Science. 2012 Sep 21;337(6101):1553-6 [PMID: 22923434]
  36. Science. 2011 Oct 14;334(6053):255-8 [PMID: 21998396]
  37. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19256-61 [PMID: 19889972]
  38. Science. 2009 Nov 13;326(5955):986-91 [PMID: 19797626]
  39. Nature. 2008 May 1;453(7191):65-71 [PMID: 18362915]
  40. Nature. 2008 Nov 27;456(7221):507-10 [PMID: 18987631]
  41. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15064-9 [PMID: 18806221]
  42. Eur J Clin Invest. 2003 Mar;33(3):244-8 [PMID: 12641543]
  43. Nature. 2012 Jul 5;487(7405):104-8 [PMID: 22722865]
  44. Gut. 2010 May;59(5):595-604 [PMID: 20427394]
  45. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15823-8 [PMID: 17895374]
  46. Cell Host Microbe. 2010 Sep 16;8(3):292-300 [PMID: 20833380]
  47. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6 [PMID: 18936492]
  48. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5919-24 [PMID: 20231436]
  49. Gastroenterology. 2011 Nov;141(5):1813-20 [PMID: 21745448]
  50. Science. 2012 Jun 8;336(6086):1314-7 [PMID: 22674328]
  51. J Exp Med. 2007 Aug 6;204(8):1775-85 [PMID: 17620362]
  52. Nat Rev Immunol. 2010 Jun;10(6):415-26 [PMID: 20498668]
  53. Int J Syst Bacteriol. 1994 Oct;44(4):812-26 [PMID: 7981107]
  54. Infect Immun. 1989 Feb;57(2):559-65 [PMID: 2643576]
  55. Sci Transl Med. 2012 Jun 6;4(137):137rv6 [PMID: 22674556]
  56. Helicobacter. 2011 Sep;16 Suppl 1:26-32 [PMID: 21896082]
  57. Nat Immunol. 2010 Sep;11(9):846-53 [PMID: 20676092]
  58. FEMS Microbiol Rev. 1992 Jun;8(3-4):165-80 [PMID: 1515159]
  59. Lab Anim. 1985 Apr;19(2):111-8 [PMID: 3889493]
  60. Annu Rev Immunol. 2012;30:759-95 [PMID: 22224764]
  61. J Immunol. 2011 Feb 1;186(3):1531-7 [PMID: 21178008]
  62. J Immunol. 2010 Mar 1;184(5):2638-45 [PMID: 20124100]
  63. Nature. 2011 Dec 11;481(7380):199-203 [PMID: 22158124]
  64. Immunol Rev. 2008 Dec;226:172-90 [PMID: 19161424]
  65. EMBO Rep. 2012 May 01;13(5):440-7 [PMID: 22422004]
  66. Interdiscip Perspect Infect Dis. 2008;2008:175285 [PMID: 19277099]
  67. Semin Immunol. 2012 Feb;24(1):43-9 [PMID: 22137188]
  68. DNA Res. 2011 Aug;18(4):291-303 [PMID: 21791478]
  69. Immunol Res. 2012 Dec;54(1-3):37-49 [PMID: 22562804]
  70. Gastroenterology. 1992 Jul;103(1):51-6 [PMID: 1612357]
  71. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12204-9 [PMID: 20566854]
  72. Nat Immunol. 2001 Apr;2(4):361-7 [PMID: 11276208]
  73. Nature. 2009 Oct 29;461(7268):1282-6 [PMID: 19865172]
  74. Nature. 2008 May 29;453(7195):620-5 [PMID: 18509436]
  75. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16767-72 [PMID: 18931303]
  76. Science. 2011 May 20;332(6032):974-7 [PMID: 21512004]
  77. Science. 2011 Jan 21;331(6015):337-41 [PMID: 21205640]
  78. Gut Microbes. 2011 Mar-Apr;2(2):99-104 [PMID: 21694499]
  79. J Exp Med. 2012 Feb 13;209(2):251-8 [PMID: 22291094]
  80. Science. 2012 Apr 27;336(6080):489-93 [PMID: 22442383]
  81. Immunity. 2007 Jun;26(6):812-26 [PMID: 17570691]
  82. Nature. 2008 Oct 9;455(7214):808-12 [PMID: 18716618]
  83. Science. 2012 Apr 27;336(6080):485-9 [PMID: 22539724]
  84. Cell. 2004 Jul 23;118(2):229-41 [PMID: 15260992]
  85. Microbiol Immunol. 1995;39(8):555-62 [PMID: 7494493]
  86. J Immunol. 2006 Sep 15;177(6):4072-9 [PMID: 16951371]
  87. Immunity. 2008 Oct 17;29(4):637-49 [PMID: 18835196]
  88. Nature. 2008 May 1;453(7191):106-9 [PMID: 18362914]
  89. Int J Syst Bacteriol. 1995 Oct;45(4):780-2 [PMID: 7547299]
  90. Nature. 2007 Sep 20;449(7160):361-5 [PMID: 17694047]
  91. Science. 2009 Dec 18;326(5960):1694-7 [PMID: 19892944]
  92. Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13780-5 [PMID: 17699621]
  93. J Infect Dis. 2000 Mar;181(3):1027-33 [PMID: 10720527]
  94. Infect Immun. 1993 Sep;61(9):4001-4 [PMID: 8359925]
  95. Nat Rev Microbiol. 2012 Sep;10(9):607-17 [PMID: 22864264]
  96. Nat Rev Microbiol. 2008 Feb;6(2):121-31 [PMID: 18180751]
  97. Nature. 2012 Jul 25;487(7408):477-81 [PMID: 22837003]
  98. J Exp Med. 2007 Aug 6;204(8):1757-64 [PMID: 17620361]
  99. J Immunol. 2010 Apr 1;184(7):3433-41 [PMID: 20181882]
  100. Cell. 2005 Jul 15;122(1):107-18 [PMID: 16009137]
  101. Gastroenterology. 2012 Nov;143(5):1288-1297 [PMID: 22850180]
  102. Nat Immunol. 2011 Mar;12(3):264-70 [PMID: 21258321]
  103. Cell. 2009 Oct 30;139(3):485-98 [PMID: 19836068]
  104. Microb Ecol. 1982 Oct;8(2):181-90 [PMID: 24225812]
  105. Nat Immunol. 2011 Apr;12(4):320-6 [PMID: 21336274]
  106. Cell Host Microbe. 2011 May 19;9(5):390-403 [PMID: 21575910]
  107. Cell. 2006 Sep 22;126(6):1121-33 [PMID: 16990136]

Grants

  1. R00 DK085329/NIDDK NIH HHS

MeSH Term

Animals
Gastrointestinal Tract
Humans
Immune System
Metagenome
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 19

Word Cloud

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