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Current hypertension reports
Feb, 2013;15 (1): 39-46.

The role of type 1 angiotensin receptors on T lymphocytes in cardiovascular and renal diseases.

Jiandong Zhang, Steven D Crowley
Author Information
  1. Jiandong Zhang: Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, DUMC, Durham, NC 27710, USA.
PMID: 23160867 DOI: 10.1007/s11906-012-0318-z

Abstract

The renin-angiotensin system plays a critical role in the pathogenesis of several cardiovascular diseases, largely through activation of type I angiotensin (AT(1)) receptors by angiotensin II. Treatment with AT(1) receptor blockers (ARBs) is a proven successful intervention for hypertension and progressive heart and kidney disease. However, the divergent actions of AT(1) receptors on individual cell lineages in hypertension may present novel opportunities to optimize the therapeutic benefits of ARBs. For example, T lymphocytes make important contributions to the induction and progression of various cardiovascular diseases, but new experiments indicate that activation of AT(1) receptors on T cells paradoxically limits inflammation and target organ damage in hypertension. Future studies should illustrate how these discrepant functions of AT(1) receptors in target organs versus mononuclear cells can be exploited for the benefit of patients with recalcitrant hypertension and other cardiovascular diseases.

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Grants

  1. R01 DK087893/NIDDK NIH HHS
  2. R01 DK087783/NIDDK NIH HHS
  3. I01 BX000893/BLRD VA
  4. U01 DK087783/NIDDK NIH HHS
  5. DK087783/NIDDK NIH HHS

MeSH Term

Angiotensin Receptor Antagonists
Animals
Atherosclerosis
B-Lymphocytes
Cardiovascular Diseases
Cell Proliferation
Disease Progression
Heart Failure
Humans
Hypertension
Kidney Diseases
Receptor, Angiotensin, Type 1
Renin-Angiotensin System
T-Lymphocytes
Wound Healing

Chemicals

Angiotensin Receptor Antagonists
Receptor, Angiotensin, Type 1
Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.
Article has an altmetric score of 1

Word Cloud

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