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Epidemiology and infection
Sep, 2013;141 (9): 1983-92.

Changing epidemiology of methicillin-resistant Staphylococcus aureus colonization in paediatric intensive-care units.

C R Hermos, T J Sandora, L E Williams, N Mosammaparast, A J McAdam
Author Information
  1. C R Hermos: Division of Paediatric Immunology and Infectious Diseases, UMass Memorial Children's Medical Center, Worcester, MA, USA. Christina.hermos@umassmemorial.org
PMID: 23190509 DOI: 10.1017/S0950268812002476

Abstract

Community-associated methicillin-resistant S. aureus (CA-MRSA) accounts for a growing proportion of hospital-onset infections, and colonization is a risk factor. This study aimed to determine changes in the prevalence of CA-MRSA colonization in paediatric intensive-care units (ICUs). A total of 495 paediatric patients colonized with MRSA from neonatal, medical, surgical, and cardiac ICUs between 2001 and 2009 were identified. Isolates were characterized by spa type, staphylococcal cassette chromosome (SCC) mec type and the presence of the genes encoding Panton–Valentine leukocidin (PVL). The proportion of patients colonized with MRSA remained stable (average 3·2%). The proportion of isolates with spa type 1, SCCmec type IV and PVL increased over time to maximums in 2009 of 36·1% (P < 0·001), 54·2% (P = 0·03) and 28·9% (P = 0·003), respectively. Antibiotic susceptibility patterns showed increasing proportions susceptible to clindamycin, gentamicin, tetracycline and trimethoprim-sulfamethoxazole (P values <0·001). In conclusion, the proportion of MRSA-colonized children in ICUs with CA-MRSA increased significantly over time.

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MeSH Term

Adolescent
Carrier State
Child
Child, Preschool
Cohort Studies
Community-Acquired Infections
DNA, Bacterial
Female
Genes, Bacterial
Humans
Infant
Intensive Care Units, Pediatric
Male
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Molecular Typing
Prevalence
Retrospective Studies
Staphylococcal Infections

Chemicals

DNA, Bacterial
Journal Article Research Support, Non-U.S. Gov't

Word Cloud

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