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Nature structural & molecular biology
Mar, 2013;20 (3): 267-73.

Determinants of nucleosome positioning.

Kevin Struhl, Eran Segal
Author Information
  1. Kevin Struhl: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA. kevin@hms.harvard.edu
PMID: 23463311 DOI: 10.1038/nsmb.2506

Abstract

Nucleosome positioning is critical for gene expression and most DNA-related processes. Here we review the dominant patterns of nucleosome positioning that have been observed and summarize the current understanding of their underlying determinants. The genome-wide pattern of nucleosome positioning is determined by the combination of DNA sequence, ATP-dependent nucleosome remodeling enzymes and transcription factors that include activators, components of the preinitiation complex and elongating RNA polymerase II. These determinants influence each other such that the resulting nucleosome positioning patterns are likely to differ among genes and among cells in a population, with consequent effects on gene expression.

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Grants

  1. R01 CA119176/NCI NIH HHS
  2. R01 GM030186/NIGMS NIH HHS
  3. R37 GM030186/NIGMS NIH HHS
  4. GM 30186/NIGMS NIH HHS

MeSH Term

Adenosine Triphosphate
Base Sequence
Chromatin Assembly and Disassembly
DNA-Binding Proteins
Nucleosomes
Poly dA-dT
RNA Polymerase II
Transcription Factors
Yeasts

Chemicals

DNA-Binding Proteins
Nucleosomes
Transcription Factors
Poly dA-dT
Adenosine Triphosphate
RNA Polymerase II
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 19

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