Performance of the GenoType MTBDRplus assay directly on sputum specimens from Brazilian patients with tuberculosis treatment failure or relapse.

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Raquel de Abreu Maschmann, Fernanda Sá Spies, Luciana de Souza Nunes, Andrezza Wolowski Ribeiro, Taís Raquel Marcon Machado, Arnaldo Zaha, Maria Lucia Rosa Rossetti

Author Information

Raquel de Abreu Maschmann: Fundação Estadual de Produção e Pesquisa em Saúde, Porto Alegre, RS, Brazil. raquel368@gmail.com

PMID: 23467605 DOI: 10.1128/JCM.00364-13

Rapid identification of drug resistance in clinical isolates of Mycobacterium tuberculosis is important in determining treatment for tuberculosis. The aim of this work was evaluate the performance of the GenoType MDRTBplus assay directly on sputum of patients who had treatment failure or relapse in a routine outpatient setting in southern Brazil.

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Antibiotics, Antitubercular

Bacterial Proteins

Base Sequence

Brazil

Catalase

DNA, Bacterial

DNA-Directed RNA Polymerases

Drug Resistance, Multiple, Bacterial

Humans

Isoniazid

Microbial Sensitivity Tests

Molecular Diagnostic Techniques

Mutation

Mycobacterium tuberculosis

Oxidoreductases

Recurrence

Rifampin

Sequence Analysis, DNA

Sputum

Treatment Failure

Tuberculosis, Multidrug-Resistant

Antibiotics, Antitubercular

Bacterial Proteins

DNA, Bacterial

rpoB protein, Mycobacterium tuberculosis

Oxidoreductases

Catalase

katG protein, Mycobacterium tuberculosis

InhA protein, Mycobacterium

DNA-Directed RNA Polymerases

Isoniazid

Rifampin

Journal Article

Evaluation of genotype MTBDRplus VER 2.0 line probe assay for the detection of MDR-TB in smear positive and negative sputum samples.Multicenter evaluation of TB-SPRINT 59-Plex Beamedex®: accuracy and cost analysis.2-(Quinolin-4-yloxy)acetamides Are Active against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains.Genotype®MTBDRplus and Xpert®MTB/RIF in the diagnosis of tuberculosis and resistant tuberculosis: cost analysis in a tertiary referral hospital.Evaluation of Diagnostic Performance of Line Probe Assay on Smear-Negative Samples of Pulmonary Tuberculosis.Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil.Detection of tuberculosis drug resistance: a comparison by Mycobacterium tuberculosis MLPA assay versus Genotype®MTBDRplus.Correlation between the BACTEC MGIT 960 culture system with Genotype MTBDRplus and TB-SPRINT in multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil.Performance of a molecular assay to detect Mycobacterium tuberculosis complex DNA in clinical specimens: multicenter study in Brazil.Assessment of the genotype MTBDRplus assay for rifampin and isoniazid resistance detection on sputum samples in Cote d'Ivoire.

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