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Current HIV/AIDS reports
Jun, 2013;10 (2): 142-51.

Use of antiretrovirals for HIV prevention: what do we know and what don't we know?

Jared M Baeten, Robert Grant
Author Information
  1. Jared M Baeten: Department of Global Health, University of Washington, Seattle, WA 98104, USA. jbaeten@uw.edu
PMID: 23494772 DOI: 10.1007/s11904-013-0157-9

Abstract

Pre-exposure prophylaxis (PrEP), in which HIV uninfected persons with ongoing HIV risk use antiretroviral medications as chemoprophylaxis against sexual HIV acquisition, is a promising new HIV prevention strategy. Proof-of-concept that PrEP, as oral or vaginal topical tenofovir-based products, protects against sexual HIV acquisition has been demonstrated in clinical trials conducted among men who have sex with men and heterosexual men and women. The degree of HIV protection in these trials was strongly related to the level of adherence to PrEP. Many questions are yet unanswered--including how to motivate uptake of and sustain adherence to PrEP for HIV prevention, how much PrEP use is enough to achieve HIV protection, and the potential of "next-generation" PrEP agents to improve on this effective technology.

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Grants

  1. R01 AI062333/NIAID NIH HHS
  2. R01 MH095507/NIMH NIH HHS
  3. U01 AI064002/NIAID NIH HHS
  4. R01 AI064002/NIAID NIH HHS

MeSH Term

Adenine
Administration, Oral
Administration, Topical
Anti-HIV Agents
Chemoprevention
Female
HIV Infections
Humans
Male
Organophosphonates
Randomized Controlled Trials as Topic
Risk Reduction Behavior
Sexual Behavior
Tenofovir
Assessment of Medication Adherence

Chemicals

Anti-HIV Agents
Organophosphonates
Tenofovir
Adenine
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Word Cloud

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