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The Journal of organic chemistry
May 03, 2013;78 (9): 4207-13.

Overcoming resistance to β-lactam antibiotics.

Roberta J Worthington, Christian Melander
Author Information
  1. Roberta J Worthington: Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
PMID: 23530949 DOI: 10.1021/jo400236f

Abstract

β-Lactam antibiotics are one of the most important antibiotic classes but are plagued by problems of resistance, and the development of new β-lactam antibiotics through side-chain modification of existing β-lactam classes is not keeping pace with resistance development. In this JOCSynopsis, we summarize small molecule strategies to overcome resistance to β-lactam antibiotics. These approaches include the development of β-lactamase inhibitors and compounds that interfere with the ability of the bacteria to sense an antibiotic threat and activate their resistance mechanisms.

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Grants

  1. R01 GM055769/NIGMS NIH HHS
  2. R21 AI096015/NIAID NIH HHS
  3. R01GM055769/NIGMS NIH HHS
  4. R21AI096015/NIAID NIH HHS

MeSH Term

Anti-Bacterial Agents
Drug Discovery
Molecular Structure
Small Molecule Libraries
beta-Lactam Resistance
beta-Lactamase Inhibitors
beta-Lactams

Chemicals

Anti-Bacterial Agents
Small Molecule Libraries
beta-Lactamase Inhibitors
beta-Lactams
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review
Article has an altmetric score of 8

Word Cloud

Created with Highcharts 10.0.0resistanceantibioticsβ-lactamdevelopmentantibioticclassesβ-Lactamoneimportantplaguedproblemsnewside-chainmodificationexistingkeepingpaceJOCSynopsissummarizesmallmoleculestrategiesovercomeapproachesincludeβ-lactamaseinhibitorscompoundsinterfereabilitybacteriasensethreatactivatemechanismsOvercoming

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