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2013 Nov-Dec;4 (6): 494-504.

Unintended consequences of Helicobacter pylori infection in children in developing countries: iron deficiency, diarrhea, and growth retardation.

Dulciene M M Queiroz, Andreia M C Rocha, Jean E Crabtree
Author Information
  1. Dulciene M M Queiroz: Laboratory of Research in Bacteriology; Faculdade de Medicina; Universidade Federal de Minas Gerais; Belo Horizonte, Brazil.
  2. Andreia M C Rocha: Laboratory of Research in Bacteriology; Faculdade de Medicina; Universidade Federal de Minas Gerais; Belo Horizonte, Brazil.
  3. Jean E Crabtree: Leeds Institute Molecular Medicine; St. James's University Hospital; University of Leeds; Leeds, UK.
PMID: 23988829 DOI: 10.4161/gmic.26277

Abstract

Helicobacter pylori infection is predominantly acquired early in life. The prevalence of the infection in childhood is low in developed countries, whereas in developing countries most children are infected by 10 y of age. In poor resource settings, where malnutrition, parasitic/enteropathogen and H. pylori infection co-exist in young children, H. pylori might have potentially more diverse clinical outcomes. This paper reviews the impact of childhood H. pylori infection in developing countries that should now be the urgent focus of future research. The extra-gastric manifestations in early H. pylori infection in infants in poor resource settings might be a consequence of the infection associated initial hypochlorhydria. The potential role of H. pylori infection on iron deficiency, growth impairment, diarrheal disease, malabsorption and cognitive function is discussed in this review.

Keywords

Helicobacter pylori children cognitive impairment developing countries diarrhea growth retardation hypochlorhydria iron deficiency malabsorption

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MeSH Term

Anemia, Iron-Deficiency
Child
Child, Preschool
Developing Countries
Diarrhea
Growth Disorders
Helicobacter Infections
Helicobacter pylori
Humans
Infant
Malabsorption Syndromes
Prevalence
Randomized Controlled Trials as Topic
Journal Article Research Support, Non-U.S. Gov't Review

Word Cloud

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