Exercise-induced oxygen desaturation in COPD patients without resting hypoxemia.

Vasileios Andrianopoulos, Frits M E Franssen, Jos P I Peeters, Tim J A Ubachs, Halah Bukari, Miriam Groenen, Chris Burtin, Ioannis Vogiatzis, Emiel F M Wouters, Martijn A Spruit
Author Information
  1. Vasileios Andrianopoulos: Program Development Centre, CIRO+, Centre of Expertise for Chronic Organ Failure, Hornerheide 1, 6085 NM Horn, The Netherlands. Electronic address: vasilisandrianopoulos@ciro-horn.nl.

Abstract

Exercise-induced oxygen desaturation (EID) is associated with increased risk of mortality in chronic obstructive pulmonary disease (COPD). Several screening tests have been proposed to predict EID, including FEV1, DLCO and baseline-SpO2. We aimed to validate a proposed cut-off of baseline-SpO2 ≤95% as simple screening procedure to predict EID during six-minute walk test (6MWT). In addition, we studied the prevalence and characteristics of patients exhibited EID to SpO2nadir ≤88%. 402 non-hypoxemic COPD patients performed 6MWT. Sensitivity and specificity of baseline SpO2 ≤95% as a cut-off to predict EID and determinants of EID were investigated. 158 patients (39%) exhibited EID. The sensitivity of baseline-SpO2 ≤95% to predict EID was 81.0%, specificity 49.2%, positive and negative predictive values were 50.8% and 80.0%, respectively. In a multivariate model, DLCO <50%, FEV1 <45%, PaO2 <10kPa, baseline-SpO2 <95%, and female sex were the strongest determinants of EID. Baseline oxygen saturation solely is inaccurate to predict EID. A combination of clinical characteristics (DLCO, FEV1, PaO2, baseline-SpO2, sex) increases the odds for EID in COPD.

Keywords

MeSH Term

Aged
Aged, 80 and over
Exercise Test
Female
Forced Expiratory Volume
Humans
Hypoxia
Male
Middle Aged
Outcome Assessment, Health Care
Oximetry
Oxygen
Pulmonary Disease, Chronic Obstructive
ROC Curve
Reproducibility of Results
Rest
Walking

Chemicals

Oxygen

Word Cloud

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