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Nov, 2013;12 (11): 991-1003.

Stimuli-responsive nanocarriers for drug delivery.

Simona Mura, Julien Nicolas, Patrick Couvreur
Author Information
  1. Simona Mura: Institut Galien Paris-Sud, Université Paris-Sud, UMR CNRS 8612, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, F-92296 Châtenay-Malabry Cedex, France.
PMID: 24150417 DOI: 10.1038/nmat3776

Abstract

Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible. Implementation of such devices requires the use of biocompatible materials that are susceptible to a specific physical incitement or that, in response to a specific stimulus, undergo a protonation, a hydrolytic cleavage or a (supra)molecular conformational change. In this Review, we discuss recent advances in the design of nanoscale stimuli-responsive systems that are able to control drug biodistribution in response to specific stimuli, either exogenous (variations in temperature, magnetic field, ultrasound intensity, light or electric pulses) or endogenous (changes in pH, enzyme concentration or redox gradients).

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MeSH Term

Animals
Clinical Trials as Topic
Drug Carriers
Humans
Nanostructures
Nanotechnology

Chemicals

Drug Carriers
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 15

Word Cloud

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