Juvenile Myelomonocytic Leukemia in a Premature Neonate Mimicking Neonatal Sepsis.

Ming-Luen Lee, Hsiu-Ju Yen, Shu-Jen Chen, Giun-Yi Hung, Pei-Chen Tsao, Wen-Jue Soong
Author Information
  1. Ming-Luen Lee: Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
  2. Hsiu-Ju Yen: Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC. Electronic address: hjyen2@vghtpe.gov.tw.
  3. Shu-Jen Chen: Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
  4. Giun-Yi Hung: Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
  5. Pei-Chen Tsao: Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC; Institute of Emergency and Critical Care Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
  6. Wen-Jue Soong: Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC; Institute of Emergency and Critical Care Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.

Abstract

Juvenile myelomonocytic leukemia (JMML) is a rare hematologic malignancy in children. Its presentations include anemia, thrombocytopenia, monocytosis, skin rash, marked hepatomegaly, and/or splenomegaly. Fever and respiratory involvement are common. Here, we report a case of a premature neonate with initial symptoms of respiratory distress. She gradually developed clinical manifestations of JMML that mimicked neonatal sepsis. Three weeks after birth, JMML was diagnosed. This is the first reported case of JMML presenting in a premature infant in Taiwan.

Keywords

MeSH Term

Diagnosis, Differential
Female
Humans
Infant, Newborn
Infant, Premature
Leukemia, Myelomonocytic, Juvenile
Neonatal Sepsis
Respiratory Distress Syndrome, Newborn

Word Cloud

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