PMS: a panoptic motif search tool.

Hieu Dinh, Sanguthevar Rajasekaran
Author Information
  1. Hieu Dinh: Computer Science and Engineering Department, University of Connecticut, Storrs, Connecticut, United States of America.

Abstract

BACKGROUND: Identification of DNA/Protein motifs is a crucial problem for biologists. Computational techniques could be of great help in this identification. In this direction, many computational models for motifs have been proposed in the literature.
METHODS: One such important model is the (l,d) motif model. In this paper we describe a motif search web tool that predominantly employs this motif model. This web tool exploits the state-of-the art algorithms for solving the (l,d) motif search problem.
RESULTS: The online tool has been helping scientists identify many unknown motifs. Many of our predictions have been successfully verified as well. We hope that this paper will expose this crucial tool to many more scientists.
AVAILABILITY AND REQUIREMENTS: Project name: PMS--Panoptic Motif Search Tool. Project home page: http://pms.engr.uconn.edu or http://motifsearch.com. Licence: PMS tools will be readily available to any scientist wishing to use it for non-commercial purposes, without restrictions. The online tool is freely available without login.

References

  1. Bioinformatics. 2002;18 Suppl 1:S354-63 [PMID: 12169566]
  2. BMC Bioinformatics. 2011 Oct 24;12:410 [PMID: 22024209]
  3. PLoS One. 2012;7(7):e41425 [PMID: 22848493]
  4. Int J Bioinform Res Appl. 2014;10(6):559-73 [PMID: 25335563]
  5. Nat Biotechnol. 2005 Jan;23(1):137-44 [PMID: 15637633]
  6. Protein Sci. 1995 Aug;4(8):1587-95 [PMID: 8520485]
  7. Front Biosci (Landmark Ed). 2009 Jun 01;14:5052-65 [PMID: 19482604]
  8. J Comput Biol. 2005 Oct;12(8):1117-28 [PMID: 16241901]
  9. Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W350-5 [PMID: 16845024]
  10. IEEE/ACM Trans Comput Biol Bioinform. 2007 Oct-Dec;4(4):544-52 [PMID: 17975266]
  11. PLoS One. 2007 Oct 03;2(10):e967 [PMID: 17912346]
  12. PLoS One. 2010 Dec 29;5(12):e14444 [PMID: 21206902]
  13. Nucleic Acids Res. 2009 Jul;37(Web Server issue):W202-8 [PMID: 19458158]
  14. Nucleic Acids Res. 2006 Jul 19;34(12):3546-54 [PMID: 16855291]

Grants

  1. R01 LM010101/NLM NIH HHS
  2. R01-LM010101/NLM NIH HHS

MeSH Term

Algorithms
Amino Acid Motifs
DNA
DNA-Binding Proteins
Molecular Sequence Data
Nucleotide Motifs
Search Engine
Software

Chemicals

DNA-Binding Proteins
DNA

Word Cloud

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