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Genesis (New York, N.Y. : 2000)
Mar, 2014;52 (3): 279-86.

Every which way--nanos gene regulation in echinoderms.

Nathalie Oulhen, Gary M Wessel
Author Information
  1. Nathalie Oulhen: Department of Molecular and Cell Biology and Biochemistry, Brown University, Providence, Rhode Island.
PMID: 24376110 DOI: 10.1002/dvg.22737

Abstract

Nanos is an essential factor of germ line success in all animals tested. This gene encodes a Zn-finger RNA-binding protein that in complex with its partner pumilio binds to and changes the fate of several known transcripts. We summarize here the documented functions of Nanos in several key organisms, and then emphasize echinoderms as a working model for how nanos expression is regulated. Nanos presence outside of the target cells is often detrimental to the animal, and in sea urchins, nanos expression appears to be regulated at every step of transcription, and post-transcriptional activity, making this gene product exciting, every which way.

Keywords

germ line primordial germ cells sea star sea urchin starfish

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Grants

  1. R01 HD028152/NICHD NIH HHS

MeSH Term

Animals
Cell Lineage
Drosophila Proteins
Echinodermata
Gene Expression Regulation
Germ Cells
RNA-Binding Proteins
Species Specificity

Chemicals

Drosophila Proteins
RNA-Binding Proteins
pum protein, Drosophila
nos protein, Drosophila
Journal Article Research Support, U.S. Gov't, Non-P.H.S. Review

Word Cloud

Created with Highcharts 10.0.0NanosgermgenesealineseveralechinodermsnanosexpressionregulatedcellseveryessentialfactorsuccessanimalstestedencodesZn-fingerRNA-bindingproteincomplexpartnerpumiliobindschangesfateknowntranscriptssummarizedocumentedfunctionskeyorganismsemphasizeworkingmodelpresenceoutsidetargetoftendetrimentalanimalurchinsappearssteptranscriptionpost-transcriptionalactivitymakingproductexcitingwayEveryway--nanosregulationprimordialstarurchinstarfish

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