Unusual presentation of vivax malaria with anaemia, thrombocytopenia, jaundice, renal disturbance, and melena: a report from malang, a nonendemic area in indonesia.

Loeki Enggar Fitri, Teguh Wahju Sardjono, Bagus Hermansyah, Didi Candradikusuma, Nicole Berens-Riha
Author Information
  1. Loeki Enggar Fitri: Department of Parasitology, Faculty of Medicine, University of Brawijaya, Jalan Veteran Malang, East Java 65145, Indonesia.
  2. Teguh Wahju Sardjono: Department of Parasitology, Faculty of Medicine, University of Brawijaya, Jalan Veteran Malang, East Java 65145, Indonesia.
  3. Bagus Hermansyah: Department of Parasitology, Faculty of Medicine, University of Jember, Jalan Kalimantan 37 Kampus Tegalboto, Jember East Java 68121, Indonesia.
  4. Didi Candradikusuma: Department of Internal Medicine, Dr. Saiful Anwar Hospital/Faculty of Medicine, University of Brawijaya, Jalan Veteran Malang, East Java 65145, Indonesia.
  5. Nicole Berens-Riha: Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Leopoldstrasse 5, 80802 Munich, Germany.

Abstract

Most of the complications of malaria such as anaemia, thrombocytopenia, jaundice, and renal failure are commonly found in Plasmodium falciparum malaria, but the incidence of severe and complicated vivax malaria tends to be increasing. We report two cases of severe Plasmodium vivax malaria from Malang, a nonendemic area in Indonesia. patients exhibited anaemia, thrombocytopenia, jaundice, renal disturbance, and melena. Microscopic peripheral blood examination and amplification of parasite 18s rRNA by polymerase chain reaction showed the presence of P. vivax and absence of P. falciparum. All patients responded well to antimalarial drugs.

References

  1. J Infect Dis. 2005 Jul 15;192(2):323-30 [PMID: 15962228]
  2. BMC Public Health. 2013 Jul 08;13:637 [PMID: 23834734]
  3. PLoS Med. 2008 Jun 17;5(6):e136 [PMID: 18563965]
  4. J Assoc Physicians India. 2012 Oct;60:15-8 [PMID: 23777019]
  5. Malar J. 2010 Jan 13;9:13 [PMID: 20070895]
  6. Am J Trop Med Hyg. 2009 Feb;80(2):194-8 [PMID: 19190212]
  7. Malar J. 2012 Apr 27;11:135 [PMID: 22540175]
  8. Emerg Infect Dis. 2013 Oct;19(10):1605-11 [PMID: 24050302]
  9. Emerg Infect Dis. 2010 Oct;16(10):1611-4 [PMID: 20875292]
  10. Crit Care. 2003 Aug;7(4):315-23 [PMID: 12930555]
  11. Braz J Infect Dis. 2002 Oct;6(5):263-5 [PMID: 12495609]
  12. Emerg Infect Dis. 2010 Jun;16(6):1033-4 [PMID: 20507769]
  13. Indian Pediatr. 1996 Nov;33(11):971-2 [PMID: 9141839]
  14. J Vector Borne Dis. 2013 Mar;50(1):71-3 [PMID: 23703445]
  15. Malar J. 2013 Sep 10;12:315 [PMID: 24020374]
  16. PLoS Med. 2008 Jun 17;5(6):e128 [PMID: 18563962]
  17. PLoS One. 2011;6(6):e21315 [PMID: 21738634]
  18. J Vector Borne Dis. 2012 Mar;49(1):49-51 [PMID: 22585247]
  19. Indian Pediatr. 2007 Jun;44(6):433-4 [PMID: 17620697]

Word Cloud

Created with Highcharts 10.0.0malariavivaxanaemiathrombocytopeniajaundicerenalPlasmodiumfalciparumseverereportnonendemicareadisturbancePcomplicationsfailurecommonlyfoundincidencecomplicatedtendsincreasingtwocasesMalangIndonesiaPatientsexhibitedmelenaMicroscopicperipheralbloodexaminationamplificationparasite18srRNApolymerasechainreactionshowedpresenceabsencepatientsrespondedwellantimalarialdrugsUnusualpresentationmelena:malangindonesia

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