Crystal structure of Marburg virus VP24.

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Adrianna P P Zhang, Zachary A Bornholdt, Dafna M Abelson, Erica Ollmann Saphire

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Adrianna P P Zhang: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.

PMID: 24574400 DOI: 10.1128/JVI.03565-13

The VP24 protein plays an essential, albeit poorly understood role in the filovirus life cycle. VP24 is only 30% identical between Marburg virus and the ebolaviruses. Furthermore, VP24 from the ebolaviruses is immunosuppressive, while that of Marburg virus is not. The crystal structure of Marburg virus VP24, presented here, reveals that although the core is similar between the viral genera, Marburg VP24 is distinguished by a projecting β-shelf and an alternate conformation of the N-terminal polypeptide.

PDB | 4OR8

J Infect Dis. 2011 Nov;204 Suppl 3:S953-6 [PMID: 21987775]
J Virol. 2005 Nov;79(21):13421-33 [PMID: 16227263]
PLoS Biol. 2011 Nov;9(11):e1001196 [PMID: 22110401]
J Infect Dis. 2011 Nov;204 Suppl 3:S1011-20 [PMID: 21987737]
Nucleic Acids Res. 2007 Jul;35(Web Server issue):W375-83 [PMID: 17452350]
J Infect Dis. 2011 Nov;204 Suppl 3:S919-26 [PMID: 21987770]
Methods Enzymol. 1997;276:307-26 [PMID: 27754618]
J Virol. 2006 Jul;80(13):6497-516 [PMID: 16775337]
PLoS Pathog. 2006 Jul;2(7):e73 [PMID: 16848640]
Arch Virol. 2014 Apr;159(4):821-30 [PMID: 24122154]
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [PMID: 15572765]
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21 [PMID: 20124702]
J Virol. 2003 Feb;77(3):1793-800 [PMID: 12525613]
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12289-94 [PMID: 11027311]
PLoS Pathog. 2010 Jan 15;6(1):e1000721 [PMID: 20084112]
J Infect Dis. 2007 Nov 15;196 Suppl 2:S131-5 [PMID: 17940940]
J Virol. 2007 Dec;81(24):13469-77 [PMID: 17928350]
Acta Crystallogr D Biol Crystallogr. 1994 Sep 1;50(Pt 5):760-3 [PMID: 15299374]
Virology. 2010 Jul 20;403(1):56-66 [PMID: 20444481]
J Virol. 2010 Jan;84(2):1169-75 [PMID: 19889762]
PLoS Pathog. 2012 Feb;8(2):e1002550 [PMID: 22383882]
J Infect Dis. 2007 Nov 15;196 Suppl 2:S284-90 [PMID: 17940962]
N Engl J Med. 2006 Aug 31;355(9):909-19 [PMID: 16943403]
J Virol. 2006 Jun;80(11):5156-67 [PMID: 16698996]
J Appl Crystallogr. 2007 Aug 1;40(Pt 4):658-674 [PMID: 19461840]
Bioinformatics. 2011 Dec 1;27(23):3315-6 [PMID: 21994221]
J Infect Dis. 2007 Nov 15;196 Suppl 2:S247-50 [PMID: 17940956]

T32 AI007244/NIAID NIH HHS
5P32 AI007244/NIAID NIH HHS

Crystallography, X-Ray

Models, Molecular

Protein Conformation

Viral Proteins

VP24 protein, Marburg virus

Viral Proteins

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

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