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PloS one
2014;9 (3): e91642.

Clinical manifestations of bacteremia caused by Aeromonas species in southern Taiwan.

Hung-Jen Tang, Chih-Cheng Lai, Hsin-Lan Lin, Chien-Ming Chao
Author Information
  1. Hung-Jen Tang: Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
  2. Chih-Cheng Lai: Department of Intensive Care Medicine, and Chi Mei Medical Center, Liouying, Tainan, Taiwan.
  3. Hsin-Lan Lin: Department of Nursing, Chi Mei Medical Center, Liouying, Tainan, Taiwan.
  4. Chien-Ming Chao: Department of Intensive Care Medicine, and Chi Mei Medical Center, Liouying, Tainan, Taiwan; Department of Nursing, Min-Hwei College of Health Care Management, Tainan, Taiwan.
PMID: 24614100 DOI: 10.1371/journal.pone.0091642

Abstract

AIM: This study is conducted to investigate the clinical characteristics of patients with bacteremia caused by Aeromonas species.
MATERIALS AND METHODS: Patients with bacteremia caused by Aeromonas species during the period 2009 to 2013 were identified from a computerized database of a regional hospital in southern Taiwan. The medical records of these patients were retrospectively reviewed.
RESULTS: A total of 91 patients with bacteremia due to Aeromonas species were identified. In addition to 16 (17.6%) primary bacteremia, the most common source of secondary infection is peritonitis (n = 27, 29.7%), followed by biliary tract infection (n = 18, 19.8%), and SSTI (n = 12, 13.2%), pneumonia (n = 9, 9.9%), catheter-related bloodstream infection (n =  5, 5.5%), and genitourinary tract infection (n = 4, 4.4%). A. hydrophila (n = 35, 38.5%) was the most common pathogen, followed by A. veronii biovar sobria (n = 31, 34.1%), A. caviae (n = 14, 15.4%), and A. veronii biovar veronii (n = 9, 9.9%). Forty-three (47.3%) patients were classified as healthcare-associated infections (HCAI) causes by Aeromonas species, and patients with HCAI were more likely to have cancer, and receive immunosuppressant than patients with community-acquired bacteremia. The overall outcomes, including rate of ICU admission, acute respiratory failure, and mortality were 33.3%, 28.6%, and 23.1%, respectively. Multivariate analysis showed that the in-hospital day mortality was significantly associated only with underlying cancer (P <.001), and initial shock (P <.001).
CONCLUSIONS: Aeromonas species should be considered one of the causative pathogens of healthcare-associated bacteremia, especially in immunocompromised patients. In addition, it can be associated with high fatality. Cancer and initial shock were the poor prognostic factors.

References

  1. J Microbiol Immunol Infect. 2009 Dec;42(6):510-5 [PMID: 20422137]
  2. Eur J Clin Microbiol Infect Dis. 2013 Aug;32(8):1069-75 [PMID: 23474673]
  3. Am J Trop Med Hyg. 2010 Nov;83(5):1123-7 [PMID: 21036850]
  4. Scand J Infect Dis. 2013 Apr;45(4):304-9 [PMID: 23163893]
  5. Burns. 2007 Mar;33(2):255-7 [PMID: 17084982]
  6. J Infect. 2000 May;40(3):267-73 [PMID: 10908022]
  7. Intern Med. 2010;49(22):2415-21 [PMID: 21088342]
  8. Am J Infect Control. 2008 Jun;36(5):309-32 [PMID: 18538699]
  9. Eur J Clin Microbiol Infect Dis. 2013 Apr;32(4):543-7 [PMID: 23135756]
  10. Gastroenterol Res Pract. 2011;2011:930826 [PMID: 22253618]
  11. Am J Trop Med Hyg. 2012 Nov;87(5):933-5 [PMID: 22964722]
  12. J Infect. 2012 Dec;65(6):573-5 [PMID: 22750150]
  13. Clin Infect Dis. 2007 Jun 1;44(11):1523-4 [PMID: 17479957]
  14. J Microbiol Immunol Infect. 2014 Apr;47(2):145-8 [PMID: 23063268]
  15. Intern Med. 2013;52(22):2517-21 [PMID: 24240790]
  16. J Korean Med Sci. 2011 Nov;26(11):1415-20 [PMID: 22065896]
  17. Clin Infect Dis. 1995 May;20(5):1298-304 [PMID: 7620014]
  18. J Infect. 2011 Feb;62(2):109-18 [PMID: 21163298]
  19. Clin Microbiol Rev. 2010 Jan;23(1):35-73 [PMID: 20065325]
  20. Eur J Clin Microbiol Infect Dis. 2013 Feb;32(2):245-51 [PMID: 22918516]
  21. J Clin Microbiol. 2009 Apr;47(4):1234-7 [PMID: 19244464]

MeSH Term

Adolescent
Adult
Aeromonas
Aged
Aged, 80 and over
Anti-Infective Agents
Bacteremia
Child
Community-Acquired Infections
Cross Infection
Female
Gram-Negative Bacterial Infections
Hospital Mortality
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Prognosis
Taiwan
Treatment Outcome
Young Adult

Chemicals

Anti-Infective Agents
Journal Article

Word Cloud

Created with Highcharts 10.0.0patientsbacteremiaAeromonasspeciesinfectioncausedveroniiidentifiedsouthernTaiwanaddition6%commonfollowedtractn = 999%55%4%biovar1%3%healthcare-associatedHCAIcancermortalityassociatedP<001initialshockAIM:studyconductedinvestigateclinicalcharacteristicsMATERIALSANDMETHODS:Patientsperiod20092013computerizeddatabaseregionalhospitalmedicalrecordsretrospectivelyreviewedRESULTS:total91due1617primarysourcesecondaryperitonitisn = 27297%biliaryn = 18198%SSTIn = 12132%pneumoniacatheter-relatedbloodstreamn = genitourinaryn = 44hydrophilan = 3538pathogensobrian = 3134caviaen = 1415Forty-three47classifiedinfectionscauseslikelyreceiveimmunosuppressantcommunity-acquiredoveralloutcomesincludingrateICUadmissionacuterespiratoryfailure332823respectivelyMultivariateanalysisshowedin-hospitaldaysignificantlyunderlyingCONCLUSIONS:consideredonecausativepathogensespeciallyimmunocompromisedcanhighfatalityCancerpoorprognosticfactorsClinicalmanifestations

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