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Biochimica et biophysica acta
Aug, 2014;1844 (8): 1335-43.

Thiol-based redox switches.

Bastian Groitl, Ursula Jakob
Author Information
  1. Bastian Groitl: Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
  2. Ursula Jakob: Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: ujakob@umich.edu.
PMID: 24657586 DOI: 10.1016/j.bbapap.2014.03.007

Abstract

Regulation of protein function through thiol-based redox switches plays an important role in the response and adaptation to local and global changes in the cellular levels of reactive oxygen species (ROS). Redox regulation is used by first responder proteins, such as ROS-specific transcriptional regulators, chaperones or metabolic enzymes to protect cells against mounting levels of oxidants, repair the damage and restore redox homeostasis. Redox regulation of phosphatases and kinases is used to control the activity of select eukaryotic signaling pathways, making reactive oxygen species important second messengers that regulate growth, development and differentiation. In this review we will compare different types of reversible protein thiol modifications, elaborate on their structural and functional consequences and discuss their role in oxidative stress response and ROS adaptation. This article is part of a Special Issue entitled: Thiol-Based Redox Processes.

Keywords

Disulfide bond Oxidative stress Redox regulation Sulfenic acid

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Grants

  1. R01 GM065318/NIGMS NIH HHS
  2. R01 GM102829/NIGMS NIH HHS
  3. R21 AI097893/NIAID NIH HHS
  4. GM065318/NIGMS NIH HHS

MeSH Term

Animals
Humans
Oxidation-Reduction
Oxidative Stress
Reactive Oxygen Species
Signal Transduction
Sulfhydryl Compounds

Chemicals

Reactive Oxygen Species
Sulfhydryl Compounds
Journal Article Research Support, N.I.H., Extramural Review

Word Cloud

Created with Highcharts 10.0.0RedoxredoxregulationproteinswitchesimportantroleresponseadaptationlevelsreactiveoxygenspeciesROSusedstressRegulationfunctionthiol-basedplayslocalglobalchangescellularfirstresponderproteinsROS-specifictranscriptionalregulatorschaperonesmetabolicenzymesprotectcellsmountingoxidantsrepairdamagerestorehomeostasisphosphataseskinasescontrolactivityselecteukaryoticsignalingpathwaysmakingsecondmessengersregulategrowthdevelopmentdifferentiationreviewwillcomparedifferenttypesreversiblethiolmodificationselaboratestructuralfunctionalconsequencesdiscussoxidativearticlepartSpecialIssueentitled:Thiol-BasedProcessesThiol-basedDisulfidebondOxidativeSulfenicacid

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