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Marine drugs
Mar 06, 2014;12 (3): 1208-19.

Two new antibiotic pyridones produced by a marine fungus, Trichoderma sp. strain MF106.

Bin Wu, Vanessa Oesker, Jutta Wiese, Rolf Schmaljohann, Johannes F Imhoff
Author Information
  1. Bin Wu: Kieler Wirkstoff-Zentrum am GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel, Kiel 24105, Germany. wubin@zju.edu.cn.
  2. Vanessa Oesker: Kieler Wirkstoff-Zentrum am GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel, Kiel 24105, Germany. vlutz@geomar.de.
  3. Jutta Wiese: Kieler Wirkstoff-Zentrum am GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel, Kiel 24105, Germany. jwiese@geomar.de.
  4. Rolf Schmaljohann: Kieler Wirkstoff-Zentrum am GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel, Kiel 24105, Germany. rschmaljohann@geomar.de.
  5. Johannes F Imhoff: Kieler Wirkstoff-Zentrum am GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel, Kiel 24105, Germany. jimhoff@geomar.de.
PMID: 24663111 DOI: 10.3390/md12031208

Abstract

Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC₅₀ values of 24 μM and 4 μM, respectively.

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MeSH Term

Animals
Anti-Bacterial Agents
Atlantic Ocean
Bacteria
Benzopyrans
Carbohydrate Sequence
Cell Line, Tumor
Culture Media
Cyclization
Drug Screening Assays, Antitumor
Fermentation
Humans
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Microscopy, Electron, Scanning
Models, Molecular
Molecular Conformation
Molecular Sequence Data
Mycelium
Pyridones
Seawater
Staphylococcus epidermidis
Trichoderma

Chemicals

Anti-Bacterial Agents
Benzopyrans
Culture Media
Pyridones
trichodin A
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 2

Word Cloud

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