Arko-Boham Benjamin: Department of Histology and Embryology, Dalian Medical University, 9 Western Section, Lvshun South Road, Lvshunkou District, Dalian 116044, PR China; Liaoning Provincial Key Laboratory for Proteomics, Dalian Medical University, 9 Western Section, Lvshun South Road, Dalian 116044, PR China; School of Allied Health Sciences, University of Ghana, P. O. Box KB143, Accra, Ghana.
Xin Zhou: Department of Histology and Embryology, Dalian Medical University, 9 Western Section, Lvshun South Road, Lvshunkou District, Dalian 116044, PR China; Liaoning Provincial Key Laboratory for Proteomics, Dalian Medical University, 9 Western Section, Lvshun South Road, Dalian 116044, PR China.
Okai Isaac: Department of Histology and Embryology, Dalian Medical University, 9 Western Section, Lvshun South Road, Lvshunkou District, Dalian 116044, PR China; Liaoning Provincial Key Laboratory for Proteomics, Dalian Medical University, 9 Western Section, Lvshun South Road, Dalian 116044, PR China; Department of Anatomy, SMS, Kwame Nkrumah University of Science and Technology, PMB, Kumasi, Ghana.
Haoqi Zhao: Department of Histology and Embryology, Dalian Medical University, 9 Western Section, Lvshun South Road, Lvshunkou District, Dalian 116044, PR China; Liaoning Provincial Key Laboratory for Proteomics, Dalian Medical University, 9 Western Section, Lvshun South Road, Dalian 116044, PR China.
Yang Song: Department of Histology and Embryology, Dalian Medical University, 9 Western Section, Lvshun South Road, Lvshunkou District, Dalian 116044, PR China; Liaoning Provincial Key Laboratory for Proteomics, Dalian Medical University, 9 Western Section, Lvshun South Road, Dalian 116044, PR China.
Xinming Chi: Department of Histology and Embryology, Dalian Medical University, 9 Western Section, Lvshun South Road, Lvshunkou District, Dalian 116044, PR China; Liaoning Provincial Key Laboratory for Proteomics, Dalian Medical University, 9 Western Section, Lvshun South Road, Dalian 116044, PR China.
Bing Sun: Department of Chest Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, PR China.
Lihong Hao: Department of Histology and Embryology, Dalian Medical University, 9 Western Section, Lvshun South Road, Lvshunkou District, Dalian 116044, PR China; Liaoning Provincial Key Laboratory for Proteomics, Dalian Medical University, 9 Western Section, Lvshun South Road, Dalian 116044, PR China.
Liyuan Zhang: Liaoning Provincial Key Laboratory for Proteomics, Dalian Medical University, 9 Western Section, Lvshun South Road, Dalian 116044, PR China.
Lu Liu: Liaoning Provincial Key Laboratory for Proteomics, Dalian Medical University, 9 Western Section, Lvshun South Road, Dalian 116044, PR China.
Hongwei Guan: Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, PR China.
Shujuan Shao: Department of Histology and Embryology, Dalian Medical University, 9 Western Section, Lvshun South Road, Lvshunkou District, Dalian 116044, PR China; Liaoning Provincial Key Laboratory for Proteomics, Dalian Medical University, 9 Western Section, Lvshun South Road, Dalian 116044, PR China. Electronic address: shaoshujuan2006@126.com.
Precursor messenger RNA processing factor 19 (PRP19) is known to be a critical component of the eukaryotic spliceosomal machinery and DNA damage repair system, the deregulation of which leads to many disease conditions. In many humancancers, PRP19 expression is upregulated, but its functional significance and corresponding underlying mechanisms remain to be addressed. Focusing on lung carcinomas, PRP19 upregulation was achieved by plasmid transfection into A549 adenocarcinoma cells. The transfected cells were then subjected to several in vitro and in vivo assays following in situ assessment of the protein in paired clinical lung tissues. We report that PRP19 expression is elevated in lung carcinoma tissues compared to non-tumor tissues. Following its upregulation, PRP19 repressed cell proliferation and tumor growth by upregulating the expression of the cell cycle arrest protein p21.
