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Genesis (New York, N.Y. : 2000)
Jun, 2014;52 (6): 636-55.

Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish.

Tagide N deCarvalho, Abhignya Subedi, Jason Rock, Brian D Harfe, Christine Thisse, Bernard Thisse, Marnie E Halpern, Elim Hong
Author Information
  1. Tagide N deCarvalho: Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland.
PMID: 24753112 DOI: 10.1002/dvg.22785

Abstract

The role of the habenular nuclei in modulating fear and reward pathways has sparked a renewed interest in this conserved forebrain region. The bilaterally paired habenular nuclei, each consisting of a medial/dorsal and lateral/ventral nucleus, can be further divided into discrete subdomains whose neuronal populations, precise connectivity, and specific functions are not well understood. An added complexity is that the left and right habenulae show pronounced morphological differences in many non-mammalian species. Notably, the dorsal habenulae of larval zebrafish provide a vertebrate genetic model to probe the development and functional significance of brain asymmetry. Previous reports have described a number of genes that are expressed in the zebrafish habenulae, either in bilaterally symmetric patterns or more extensively on one side of the brain than the other. The goal of our study was to generate a comprehensive map of the zebrafish dorsal habenular nuclei, by delineating the relationship between gene expression domains, comparing the extent of left-right asymmetry at larval and adult stages, and identifying potentially functional subnuclear regions as defined by neurotransmitter phenotype. Although many aspects of habenular organization appear conserved with rodents, the zebrafish habenulae also possess unique properties that may underlie lateralization of their functions.

Keywords

ano2 epithalamus gng8 habenula interpeduncular nucleus left-right asymmetry mbnl3 somatostatin

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Grants

  1. T32 GM007231/NIGMS NIH HHS
  2. F32 MH09198/NIMH NIH HHS
  3. R01 HD042215/NICHD NIH HHS
  4. F32 MH091980/NIMH NIH HHS
  5. F32 HL009198/NHLBI NIH HHS

MeSH Term

Animals
Animals, Genetically Modified
Gene Expression
Gene Expression Profiling
Gene Expression Regulation, Developmental
Genes, Reporter
Habenula
Immunohistochemistry
Neurons
Neurotransmitter Agents
Organ Specificity
Phenotype
Zebrafish

Chemicals

Neurotransmitter Agents
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
Article has an altmetric score of 7

Word Cloud

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