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Feb, 2015;388 (2): 143-52.

Interaction between Nm23 and the tumor suppressor VHL.

Chih-Hung Lin, Vincent Dammai, Boris Adryan, Tien Hsu
Author Information
  1. Chih-Hung Lin: Department of Surgery, Cathay General Hospital, Taipei, Taiwan, Republic of China.
PMID: 24915993 DOI: 10.1007/s00210-014-1002-4

Abstract

Among the anti-tumor genes (tumor suppressors and metastasis suppressors), the von-Hippel Lindau gene and the Nm23 family of genes are among the more intriguing ones. Both are small (long and short forms of VHL are 30 and 19 kD, respectively, and Nm23 is ~17 kD), and both possess diverse molecular and cellular functions. Despite extensive studies, the entire spectra of functions and the molecular function-phenotype correlation of these two proteins have not been completely elucidated. In this report, we present data showing these two proteins interact physically. We also summarize and confirm the previous studies that demonstrated the endocytic function of these two genes and further show that the endocytic function of VHL is mediated through the activity of Nm23. These functional and molecular interactions are evolutionarily conserved from Drosophila to human.

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Grants

  1. R01 CA109860/NCI NIH HHS
  2. R01CA109860/NCI NIH HHS

MeSH Term

Animals
Cell Line, Tumor
DNA, Complementary
Drosophila
Drosophila Proteins
HEK293 Cells
Humans
NM23 Nucleoside Diphosphate Kinases
Nucleoside-Diphosphate Kinase
Receptor, Fibroblast Growth Factor, Type 1
Two-Hybrid System Techniques
Von Hippel-Lindau Tumor Suppressor Protein

Chemicals

DNA, Complementary
Drosophila Proteins
NM23 Nucleoside Diphosphate Kinases
Von Hippel-Lindau Tumor Suppressor Protein
FGFR1 protein, human
Receptor, Fibroblast Growth Factor, Type 1
Nucleoside-Diphosphate Kinase
awd protein, Drosophila
Journal Article Research Support, N.I.H., Extramural
Article has an altmetric score of 9

Word Cloud

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