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BioMed research international
2014;2014 260859.

The diagnostic value of cervical lymph node metastasis in head and neck squamous carcinoma by using diffusion-weighted magnetic resonance imaging and computed tomography perfusion.

Jin Zhong, Zonghong Lu, Liang Xu, Longchun Dong, Hui Qiao, Rui Hua, Yi Gong, Zhenxing Liu, Caixian Hao, Xuehuan Liu, Changqing Zong, Li He, Jun Liu
Author Information
  1. Jin Zhong: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
  2. Zonghong Lu: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
  3. Liang Xu: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
  4. Longchun Dong: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
  5. Hui Qiao: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
  6. Rui Hua: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
  7. Yi Gong: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
  8. Zhenxing Liu: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
  9. Caixian Hao: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
  10. Xuehuan Liu: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
  11. Changqing Zong: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
  12. Li He: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
  13. Jun Liu: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
PMID: 25050333 DOI: 10.1155/2014/260859

Abstract

PURPOSE: The aim of this study was to compare diffusion-weighted magnetic resonance imaging (DWI) with computed tomography perfusion (CTP) for preoperative detection of metastases to lymph nodes (LNs) in head and neck squamous cell carcinoma (SCC).
METHODS: Between May 2010 and April 2012, 30 patients with head and neck SCC underwent preoperative DWI and CTP. Two radiologists measured apparent diffusion coefficient (ADC) values and CTP parameters independently. Surgery and histopathologic examinations were performed on all patients.
RESULTS: On DWI, 65 LNs were detected in 30 patients. The mean ADC value of metastatic nodes was lower than benign nodes and the difference was statistically significant (P < 0.05). On CTP images, the mean value in metastatic nodes of blood flow (BF) and blood volume (BV) was higher than that in benign nodes, and mean transit time (MTT) in metastatic nodes was lower than that in benign nodes. There were significant differences in BF and MTT values between metastatic and benign LNs (P < 0.05). There were significant differences between the AUCs of DWI and CTP (Z=4.612, P < 0.001).
CONCLUSION: DWI with ADC value measurements may be more accurate than CTP for the preoperative diagnosis of cervical LN metastases.

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MeSH Term

Adult
Aged
Carcinoma, Squamous Cell
Cervical Vertebrae
Diffusion Magnetic Resonance Imaging
Female
Head and Neck Neoplasms
Humans
Lymphatic Metastasis
Male
Middle Aged
Perfusion
Squamous Cell Carcinoma of Head and Neck
Tomography, X-Ray Computed
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0nodesCTPDWIvaluemetastaticbenignpreoperativeLNsheadneckpatientsADCmeansignificantP<0diffusion-weightedmagneticresonanceimagingcomputedtomographyperfusionmetastaseslymphsquamouscarcinomaSCC30valueslower05bloodBFMTTdifferencescervicalPURPOSE:aimstudycomparedetectioncellMETHODS:May2010April2012underwentTworadiologistsmeasuredapparentdiffusioncoefficientparametersindependentlySurgeryhistopathologicexaminationsperformedRESULTS:65detecteddifferencestatisticallyimagesflowvolumeBVhighertransittimeAUCsZ=4612001CONCLUSION:measurementsmayaccuratediagnosisLNdiagnosticnodemetastasisusing

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