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Molecular pharmaceutics
Feb 02, 2015;12 (2): 322-31.

Synthetic biology for therapeutic applications.

Zhanar Abil, Xiong Xiong, Huimin Zhao
Author Information
  1. Zhanar Abil: Department of Biochemistry, ‡Department of Chemical and Biomolecular Engineering, and §Department of Bioengineering, Department of Chemistry, Center for Biophysics and Computational Biology and Institute for Genomic Biology, University of Illinois at Urbana-Champaign , 600 South Mathews Avenue, Urbana, Illinois 61801, United States.
PMID: 25098838 DOI: 10.1021/mp500392q

Abstract

Synthetic biology is a relatively new field with the key aim of designing and constructing biological systems with novel functionalities. Today, synthetic biology devices are making their first steps in contributing new solutions to a number of biomedical challenges, such as emerging bacterial antibiotic resistance and cancer therapy. This review discusses some synthetic biology approaches and applications that were recently used in disease mechanism investigation and disease modeling, drug discovery and production, as well as vaccine development and treatment of infectious diseases, cancer, and metabolic disorders.

Keywords

cancer treatment disease mechanism drug discovery infectious diseases metabolic disorders synthetic biology therapeutic treatment vaccine development

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Grants

  1. P01 GM077596/NIGMS NIH HHS
  2. GM077596/NIGMS NIH HHS

MeSH Term

Animals
Drug Discovery
Humans
Synthetic Biology
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review
Article has an altmetric score of 18

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