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Neural regeneration research
Jun 01, 2014;9 (11): 1122-8.

Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats.

Xiangyu Ji, Li'na Zhang, Ran Liu, Yingzhi Liu, Jianfang Song, He Dong, Yanfang Jia, Zangong Zhou
Author Information
  1. Xiangyu Ji: Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
  2. Li'na Zhang: Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong Province, China.
  3. Ran Liu: Department of General Surgery, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
  4. Yingzhi Liu: Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
  5. Jianfang Song: Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
  6. He Dong: Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
  7. Yanfang Jia: Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
  8. Zangong Zhou: Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
PMID: 25206771 DOI: 10.4103/1673-5374.135314

Abstract

Mitochondria play an important role in neuronal apoptosis caused by cerebral ischemia, and the role is mediated by the expression of mitochondrial proteins. This study investigated the involvement of mitochondrial proteins in hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats using a comparative proteomics strategy. Our experimental results show that the aged rat brain is sensitive to ischemia-reperfusion injury and that transient ischemia led to cell apoptosis in the hippocampus and changes in memory and cognition of aged rats. Differential proteomics analysis suggested that this phenomenon may be mediated by mitochondrial proteins associated with energy metabolism and apoptosis in aged rats. This study provides potential drug targets for the treatment of transient cerebral ischemia-reperfusion injury.

Keywords

aged apoptosis cerebral ischemia cognitive function differential proteomics hippocampus mitochondria nerve regeneration neural regeneration rats reperfusion injury

References

  1. Eur J Cardiothorac Surg. 2012 May;41(5):1132-7 [PMID: 22398465]
  2. Neurochem Res. 2009 Dec;34(12):2102-16 [PMID: 19495970]
  3. Mol Cell Proteomics. 2005 Jan;4(1):12-34 [PMID: 15507458]
  4. J Inherit Metab Dis. 2011 Apr;34(2):327-44 [PMID: 20571866]
  5. Expert Opin Ther Targets. 2011 Jun;15(6):741-51 [PMID: 21391832]
  6. Contemp Top Lab Anim Sci. 2003 Mar;42(2):49-50 [PMID: 19757627]
  7. Transl Stroke Res. 2012 Jun;3(2):296-304 [PMID: 23626658]
  8. Cell Mol Life Sci. 2011 Mar;68(6):1021-31 [PMID: 21116678]
  9. Int J Stroke. 2012 Jul;7(5):398-406 [PMID: 22712741]
  10. Cell Calcium. 2012 Jul;52(1):73-85 [PMID: 22608276]
  11. Stroke. 2004 Sep;35(9):2195-9 [PMID: 15243143]
  12. Methods Cell Biol. 1998;57:297-311 [PMID: 9648112]
  13. Proteomics. 2004 Dec;4(12):3665-85 [PMID: 15543535]
  14. Dis Model Mech. 2012 Jan;5(1):125-40 [PMID: 21954064]
  15. Stroke. 1988 Jul;19(7):913-4 [PMID: 3291205]
  16. Eur Biophys J. 2011 Dec;40(12):1301-15 [PMID: 22086608]
  17. Gen Pharmacol. 1998 Apr;30(4):431-4 [PMID: 9522158]
  18. Apoptosis. 2012 Oct;17(10):1027-38 [PMID: 22865232]
  19. Brain Pathol. 2004 Oct;14(4):415-24 [PMID: 15605989]
  20. Brain Res. 2008 Dec 30;1246:178-90 [PMID: 18938146]
  21. J Proteome Res. 2010 Jan;9(1):472-84 [PMID: 19916522]
  22. J Neurochem. 2012 Sep;122(6):1219-29 [PMID: 22804628]
  23. J Cereb Blood Flow Metab. 2012 Jan;32(1):164-76 [PMID: 21878944]
  24. Mol Biol Cell. 2009 Jan;20(1):306-18 [PMID: 18971376]
  25. Cell Death Differ. 2012 Feb;19(2):267-73 [PMID: 21720385]
  26. Stroke. 1979 May-Jun;10(3):267-72 [PMID: 37614]
Journal Article

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