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Journal of manipulative and physiological therapeutics
Oct, 2014;37 (8): 552-60.

Effect of spinal manipulation thrust duration on trunk mechanical activation thresholds of nociceptive-specific lateral thalamic neurons.

William R Reed, Randall Sozio, Joel G Pickar, Stephen M Onifer
Author Information
  1. William R Reed: Associate Professor, Palmer Center for Chiropractic Research, Davenport, IA. Electronic address: william.reed@palmer.edu.
  2. Randall Sozio: Research Associate, Palmer Center for Chiropractic Research, Davenport, IA.
  3. Joel G Pickar: Professor Emeritus, Palmer Center for Chiropractic Research, Davenport, IA.
  4. Stephen M Onifer: Associate Professor, Palmer Center for Chiropractic Research, Davenport, IA.
PMID: 25220757 DOI: 10.1016/j.jmpt.2014.08.006

Abstract

OBJECTIVE: The objective of this preliminary study was to determine if high-velocity, low-amplitude spinal manipulation (HVLA-SM) thrust duration alters mechanical trunk activation thresholds of nociceptive-specific (NS) lateral thalamic neurons.
METHODS: Extracellular recordings were obtained from 18 NS neurons located in 2 lateral thalamic nuclei (ventrolateral [n = 12] and posterior [n = 6]) in normal anesthetized Wistar rats. Response thresholds to electronic von Frey anesthesiometer (rigid tip) mechanical trunk stimuli applied in 3 lumbar directions (dorsal-ventral, 45° caudal, and 45° cranial) were determined before and immediately after the delivery of 3 HVLA-SM thrust durations (time control 0, 100, and 400 milliseconds). Mean changes in mechanical trunk activation thresholds were compared using a mixed model analysis of variance.
RESULTS: High-velocity, low-amplitude spinal manipulation duration did not significantly alter NS lateral thalamic neurons' mechanical trunk responses to any of the 3 directions tested with the anesthesiometer.
CONCLUSIONS: This study is the first to examine the effect of HVLA-SM thrust duration on NS lateral thalamic mechanical response thresholds. High-velocity, low-amplitude spinal manipulation thrust duration did not affect mechanical trunk thresholds.

Keywords

Chiropractic Lumbar Vertebrae Manipulation Nociceptive Neuron Spinal Thalamus

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Grants

  1. K01AT005935/NCCIH NIH HHS
  2. P30 GM103507/NIGMS NIH HHS
  3. C06 RR015433/NCRR NIH HHS
  4. 8P30GM103507/NIGMS NIH HHS
  5. C06 RR15433/NCRR NIH HHS
  6. K01 AT005935/NCCIH NIH HHS

MeSH Term

Animals
Lateral Thalamic Nuclei
Male
Manipulation, Spinal
Nociceptors
Rats
Rats, Wistar
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
Article has an altmetric score of 2

Word Cloud

Created with Highcharts 10.0.0mechanicaltrunkthresholdsthrustdurationlateralthalamicspinalmanipulationNSlow-amplitudeHVLA-SMactivationneurons3studynociceptive-specific[n=anesthesiometerdirections45°High-velocityOBJECTIVE:objectivepreliminarydeterminehigh-velocityaltersMETHODS:Extracellularrecordingsobtained18located2nucleiventrolateral12]posterior6]normalanesthetizedWistarratsResponseelectronicvonFreyrigidtipstimuliappliedlumbardorsal-ventralcaudalcranialdeterminedimmediatelydeliverydurationstimecontrol0100400millisecondsMeanchangescomparedusingmixedmodelanalysisvarianceRESULTS:significantlyalterneurons'responsestestedCONCLUSIONS:firstexamineeffectresponseaffectEffectChiropracticLumbarVertebraeManipulationNociceptiveNeuronSpinalThalamus

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