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Indian journal of pharmaceutical sciences
Jul, 2014;76 (4): 287-98.

Relationship between Antifungal Activity against Candida albicans and Electron Parameters of Selected N-Heterocyclic Thioamides.

Jadwiga Stachowicz, Elżbieta Krajewska-Kułak, Cecylia Lukaszuk, A Niewiadomy
Author Information
  1. Jadwiga Stachowicz: University of Life Sciences in Lublin, Department of Chemistry, 15 Akademicka Street, 20-950 Lublin, Poland.
  2. Elżbieta Krajewska-Kułak: Medical University of Bialystok, Department of General Nursing, Bialystok, Poland.
  3. Cecylia Lukaszuk: Medical University of Bialystok, Department of General Nursing, Bialystok, Poland.
  4. A Niewiadomy: University of Life Sciences in Lublin, Department of Chemistry, 15 Akademicka Street, 20-950 Lublin, Poland.
PMID: 25284926

Abstract

Due to the increasing demand for new pharmaceuticals showing biological activity against pathogenic microorganisms, there is increasing search for new compounds with predicted biological activity. Variously substituted thioamide derivatives with 1.3 and 1.2 ring of thiazole and 1,3,4-thiadiazole, as well as pyrazole were assessed for their activity against Candida albicans. Activity of majority of tested thioamides was larger as compared with that of the reference drugs. The electron parameters of obtained N-heterocyclic thioamides were determined and dependencies on their biological activity against Candida albicans were studied. The best electron compliance of produced bindings with the activity against Candida albicans was observed for the derivatives containing 1,3,4-thiadiazole ring.

Keywords

Candida albicans Thioamides antifungal activity electron parameters

References

  1. Eur J Biochem. 1994 Jul 1;223(1):1-5 [PMID: 7957164]
  2. Mutat Res. 1991 Mar;247(1):97-102 [PMID: 2002808]
  3. Biol Pharm Bull. 2006 Jun;29(6):1262-6 [PMID: 16755030]
  4. J Am Chem Soc. 2001 Feb 14;123(6):1047-58 [PMID: 11456658]
  5. Drugs. 2001;61 Suppl 1:1-12 [PMID: 11219546]
  6. J Clin Microbiol. 1998 Apr;36(4):926-30 [PMID: 9542910]
  7. J Chemother. 1999 Apr;11(2):83-9 [PMID: 10326736]
  8. Proc Natl Acad Sci U S A. 1986 Nov;83(22):8440-1 [PMID: 16578791]
  9. Bioorg Med Chem. 1998 Oct;6(10):1745-57 [PMID: 9839004]
  10. Spectrochim Acta A Mol Biomol Spectrosc. 2010 Apr;75(4):1362-9 [PMID: 20129819]
  11. FEMS Microbiol Lett. 1993 Sep 15;112(3):329-33 [PMID: 8224799]
  12. Bioorg Med Chem. 2000 Jul;8(7):1741-7 [PMID: 10976522]
  13. Mycopathologia. 2009 Feb;167(2):73-9 [PMID: 18787978]
  14. Diagn Microbiol Infect Dis. 2002 Oct;44(2):163-7 [PMID: 12458123]
  15. J Infect Dis. 1993 May;167(5):1247-51 [PMID: 8486965]
  16. Oral Microbiol Immunol. 2005 Dec;20(6):349-53 [PMID: 16238594]
  17. Molecules. 2008 Jul 29;13(7):1501-17 [PMID: 18719521]
  18. Arzneimittelforschung. 1997 May;47(5):667-70 [PMID: 9205784]
  19. Bioorg Med Chem. 2002 Apr;10(4):1019-24 [PMID: 11836110]
  20. Science. 1982 Nov 19;218(4574):747-54 [PMID: 17771019]
  21. Chem Pharm Bull (Tokyo). 2006 Apr;54(4):583-7 [PMID: 16595972]
  22. Diagn Microbiol Infect Dis. 2002 Oct;44(2):169-74 [PMID: 12458124]
Journal Article

Word Cloud

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