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International journal of molecular sciences
Oct 07, 2014;15 (10): 17901-19.

Platelets: still a therapeutical target for haemostatic disorders.

Reinaldo Barros Geraldo, Pl��nio Cunha Sathler, Andr�� Luiz Louren��o, Max Seidy Saito, Lucio M Cabral, Pabulo Henrique Rampelotto, Helena Carla Castro
Author Information
  1. Reinaldo Barros Geraldo: Programa de P��s-gradua����o em Ci��ncias e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense (UFF), Niter��i CEP 24210-130, RJ, Brazil. reinaldobgeraldo@yahoo.com.br.
  2. Pl��nio Cunha Sathler: Programa de P��s-gradua����o em Patologia, Departamento de Patologia, Hospital Universit��rio Ant��nio Pedro (HUAP), Universidade Federal Fluminense (UFF), Niter��i CEP 24030-215, RJ, Brazil. pliniocs@yahoo.com.br.
  3. Andr�� Luiz Louren��o: Programa de P��s-gradua����o em Patologia, Departamento de Patologia, Hospital Universit��rio Ant��nio Pedro (HUAP), Universidade Federal Fluminense (UFF), Niter��i CEP 24030-215, RJ, Brazil. andrebiouff@gmail.com.
  4. Max Seidy Saito: Programa de P��s-gradua����o em Patologia, Departamento de Patologia, Hospital Universit��rio Ant��nio Pedro (HUAP), Universidade Federal Fluminense (UFF), Niter��i CEP 24030-215, RJ, Brazil. maxs@yahoo.com.br.
  5. Lucio M Cabral: LabTIF, Faculdade de Farm��cia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro CEP 21941-590, RJ, Brazil. pliniocs@yahoo.com.br.
  6. Pabulo Henrique Rampelotto: Interdisciplinary Center for Biotechnology Research, Federal University of Pampa, Ant��nio Trilha Avenue, P.O. Box 1847, S��o Gabriel/RS 97300-000, Brazil. pabulo@lacesm.ufsm.br.
  7. Helena Carla Castro: Programa de P��s-gradua����o em Ci��ncias e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense (UFF), Niter��i CEP 24210-130, RJ, Brazil. hcastrorangel@yahoo.com.br.
PMID: 25295482 DOI: 10.3390/ijms151017901

Abstract

Platelets are cytoplasmatic fragments from bone marrow megakaryocytes present in blood. In this work, we review the basis of platelet mechanisms, their participation in syndromes and in arterial thrombosis, and their potential as a target for designing new antithrombotic agents. The option of new biotechnological sources is also explored.

References

  1. Br J Haematol. 2009 Sep;146(6):585-96 [PMID: 19466980]
  2. J Biol Chem. 1999 Dec 17;274(51):36241-51 [PMID: 10593912]
  3. Semin Thromb Hemost. 2004 Oct;30(5):501-11 [PMID: 15497093]
  4. Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):403-12 [PMID: 18174460]
  5. Blood Transfus. 2014 Jan;12 Suppl 1:s147-8 [PMID: 24120592]
  6. Arch Pathol Lab Med. 2002 Feb;126(2):133-46 [PMID: 11825107]
  7. Chest. 2012 Feb;141(2 Suppl):e120S-e151S [PMID: 22315258]
  8. J Thromb Haemost. 2005 Aug;3(8):1725-36 [PMID: 16102039]
  9. Blood. 2013 Jul 25;122(4):580-9 [PMID: 23699602]
  10. Platelets. 2015;26(3):199-211 [PMID: 24832135]
  11. Circulation. 2002 Oct 1;106(14):1748-9 [PMID: 12356622]
  12. J Ethnopharmacol. 2014;151(1):151-7 [PMID: 24201020]
  13. Can J Anaesth. 2006 Jun;53(6 Suppl):S89-102 [PMID: 16766794]
  14. Physiol Rev. 2013 Jan;93(1):327-58 [PMID: 23303912]
  15. J Thromb Thrombolysis. 2014 Jan;37(1):4-11 [PMID: 24046067]
  16. Hematology Am Soc Hematol Educ Program. 2010;2010:387-96 [PMID: 21239824]
  17. Br J Haematol. 1986 Apr;62(4):737-45 [PMID: 2421757]
  18. Anesth Analg. 2004 Oct;99(4):989-992 [PMID: 15385338]
  19. J Thromb Haemost. 2009 Jul;7 Suppl 1:17-20 [PMID: 19630759]
  20. Thromb J. 2012 Jan 11;10(1):3 [PMID: 22236361]
  21. Nat Rev Drug Discov. 2010 Feb;9(2):154-69 [PMID: 20118963]
  22. Br J Pharmacol. 2002 Sep;137(1):107-17 [PMID: 12183336]
  23. Physiol Rev. 1989 Jan;69(1):58-178 [PMID: 2536184]
  24. Platelets. 2001 Mar;12(2):114-20 [PMID: 11297032]
  25. J Thromb Thrombolysis. 2014 Jul;38(1):11-23 [PMID: 24368727]
  26. Ann Thorac Surg. 2009 May;87(5):1633-40 [PMID: 19379937]
  27. Front Biosci. 2006 Jan 01;11:59-80 [PMID: 16146714]
  28. Crit Rev Clin Lab Sci. 2005;42(3):249-77 [PMID: 16047540]
  29. Hematology Am Soc Hematol Educ Program. 2007;:172-8 [PMID: 18024626]
  30. Semin Thromb Hemost. 2004 Oct;30(5):537-47 [PMID: 15497096]
  31. Vox Sang. 2011 Jul;101(1):1-9 [PMID: 21668862]
  32. Cancer Metastasis Rev. 2014 Mar;33(1):231-69 [PMID: 24696047]
  33. Ideggyogy Sz. 2013 Jan 30;66(1-2):15-22 [PMID: 23607225]
  34. Haemophilia. 2012 Jul;18 Suppl 4:161-5 [PMID: 22726101]
  35. Clin Appl Thromb Hemost. 2004 Apr;10(2):155-66 [PMID: 15094936]
  36. Curr Cardiovasc Imaging Rep. 2010;4(1):77-84 [PMID: 21253438]
  37. Expert Rev Hematol. 2013 Apr;6(2):205-12 [PMID: 23547868]
  38. Am J Med. 1983 Jun 14;74(6A):72-8 [PMID: 6344629]
  39. Blood. 2010 Aug 19;116(7):1147-56 [PMID: 20439620]
  40. Pharmacol Ther. 2014 Jan;141(1):69-78 [PMID: 23993980]
  41. Am J Clin Pathol. 2005 Jun;123 Suppl:S125-32 [PMID: 16100874]
  42. Clin Lab. 2004;50(9-10):559-66 [PMID: 15481631]
  43. JAMA. 2001 Aug 22-29;286(8):954-9 [PMID: 11509060]
  44. Lancet. 2006 Feb 18;367(9510):606-17 [PMID: 16488805]
  45. J Ethnopharmacol. 2014;151(1):733-9 [PMID: 24291032]
  46. Semin Thromb Hemost. 2005;31(4):381-92 [PMID: 16149014]
  47. Blood. 2000 Aug 15;96(4):1433-7 [PMID: 10942388]
  48. Br J Haematol. 2009 Nov;147(4):415-30 [PMID: 19656155]
  49. J Thromb Haemost. 2011 May;9(5):1020-8 [PMID: 21320282]
  50. Haemostasis. 1985;15(3):169-75 [PMID: 2993136]
  51. N Engl J Med. 2001 Dec 20;345(25):1809-17 [PMID: 11752357]
  52. Am J Cardiovasc Drugs. 2013 Aug;13(4):233-50 [PMID: 23613159]
  53. Interv Cardiol Clin. 2013 Oct;2(4):527-535 [PMID: 28582181]
  54. Circulation. 1999 Jan 5;99(1):E1-E11 [PMID: 9884400]
  55. Acta Med Scand Suppl. 1971;525:215-7 [PMID: 5317106]
  56. Ann Intern Med. 2002 Jan 15;136(2):161-72 [PMID: 11790072]
  57. Thromb Res. 2014 Apr;133(4):525-31 [PMID: 24438943]
  58. Sci Transl Med. 2014 Mar 12;6(227):227ra33 [PMID: 24622513]
  59. Curr Pharm Des. 2005;11(18):2331-65 [PMID: 16022671]
  60. Thromb Res. 1999 May 1;94(3):187-97 [PMID: 10326765]
  61. Cell Mol Life Sci. 2004 Sep;61(18):2361-85 [PMID: 15378206]
  62. N Engl J Med. 1975 Sep 11;293(11):531-41 [PMID: 168489]
  63. Thromb Haemost. 2001 Jul;86(1):214-21 [PMID: 11487009]
  64. Clin Hemorheol Microcirc. 2013;53(1-2):71-9 [PMID: 22954635]
  65. Cardiovasc Ther. 2013 Feb;31(1):3-11 [PMID: 21884029]
  66. Clin Chim Acta. 2008 Jan;387(1-2):1-8 [PMID: 17884033]
  67. Mol Cell Ther. 2014 Feb 01;2:4 [PMID: 26056573]
  68. Blood. 2010 Sep 16;116(11):1867-75 [PMID: 20538807]
  69. Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1152-60 [PMID: 12738684]
  70. J Blood Med. 2010 Aug 1;2010(1):147-162 [PMID: 21572574]
  71. Br J Clin Pharmacol. 2014 Aug;78(2):320-8 [PMID: 25099258]
  72. Clin Chim Acta. 2010 Jan;411(1-2):1-6 [PMID: 19854165]
  73. Pathophysiol Haemost Thromb. 2002;32 Suppl 1:47-52 [PMID: 12214148]
  74. Cell Stem Cell. 2014 Apr 3;14(4):425-6 [PMID: 24702993]
  75. Nat Clin Pract Cardiovasc Med. 2008 Dec;5(12):766-80 [PMID: 18957959]
  76. Semin Oncol. 2014 Jun;41(3):370-7 [PMID: 25023352]
  77. Circulation. 2003 Sep 30;108(13):e88-90 [PMID: 14517153]
  78. Blood Rev. 2014 May;28(3):109-21 [PMID: 24745727]
  79. Best Pract Res Clin Anaesthesiol. 2010 Mar;24(1):27-40 [PMID: 20402168]
  80. N Engl J Med. 2005 Dec 1;353(22):2373-83 [PMID: 16319386]
  81. Circulation. 2005 May 3;111(17):e267-71 [PMID: 15867186]
  82. Methods Mol Biol. 2013;992:227-40 [PMID: 23546717]
  83. Blood. 2003 Apr 1;101(7):2637-45 [PMID: 12456504]
  84. Blood Coagul Fibrinolysis. 2014 Jun;25(4):401-4 [PMID: 24418945]
  85. Thromb J. 2004 Jan 14;2(1):1 [PMID: 14723795]
  86. Biomed Res Int. 2014;2014:456569 [PMID: 24895576]
  87. Neurologia. 2015 Nov-Dec;30(9):566-73 [PMID: 24662033]
  88. Platelets. 2010;21(3):167-75 [PMID: 20196629]
  89. J Lab Clin Med. 1980 Jun;95(6):827-41 [PMID: 7381294]
  90. Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):61-71 [PMID: 24233488]
  91. Eur J Haematol. 2014;92(5):367-76 [PMID: 24400878]
  92. Br J Haematol. 2005 Jul;130(1):3-10 [PMID: 15982339]
  93. N Engl J Med. 1992 Jan 23;326(4):242-50 [PMID: 1727977]
  94. Cold Spring Harb Perspect Biol. 2012 Feb 01;4(2): [PMID: 21937733]
  95. Transfus Apher Sci. 2014 Apr;50(2):189-99 [PMID: 24685245]
  96. Curr Opin Hematol. 1995 Sep;2(5):395-401 [PMID: 9372025]
  97. N Engl J Med. 1984 Nov 8;311(19):1206-11 [PMID: 6436696]
  98. Clin Appl Thromb Hemost. 2004 Jul;10(3):195-204 [PMID: 15247976]
  99. Clin Biochem. 2009 Sep;42(13-14):1452-60 [PMID: 19560449]
  100. Expert Opin Investig Drugs. 2001 May;10(5):865-90 [PMID: 11322863]
  101. J Thromb Haemost. 2010 Jul;8(7):1643-5 [PMID: 20456745]
  102. Hematol Oncol Clin North Am. 2010 Aug;24(4):755-75, ix [PMID: 20659659]
  103. Clin Exp Immunol. 2001 Aug;125(2):283-90 [PMID: 11529921]
  104. BMJ. 2002 Jan 12;324(7329):103-5 [PMID: 11786458]
  105. Circulation. 2004 Sep 21;110(12):1706-8 [PMID: 15381661]
  106. Nature. 1993 Apr 29;362(6423):801-9 [PMID: 8479518]
  107. Thromb Haemost. 1997 Jul;78(1):611-6 [PMID: 9198225]
  108. Transfus Med Hemother. 2014 Jun;41(3):176-81 [PMID: 25053930]

MeSH Term

Aspirin
Blood Platelets
Hemostatic Disorders
Humans
Integrins
Platelet Aggregation Inhibitors
Platelet Storage Pool Deficiency
Thrombosis

Chemicals

Integrins
Platelet Aggregation Inhibitors
Aspirin
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 3

Word Cloud

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