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International journal of occupational and environmental health
2015;21 (1): 40-8.

Analysis of PAEs in semen of infertile men.

Sheng-Yuan Wang, Yu Wang, Fang-Qin Xie, Yan-Xing Li, Xue-Lian Wan, Wei-Wei Ma, De-Cai Wang, Yong-Hui Wu
Author Information
PMID: 25384258 DOI: 10.1179/2049396714Y.0000000088

Abstract

OBJECTIVES: Phthalates are environmental chemicals with reproductive toxicity and estrogenic effects in animals. They are of increasing concern to human health.
AIM: To determine whether phthalate levels in semen were associated with infertility.
METHODS: Using semen samples from 107 infertile and 94 fertile men, the presence and quantity of five phthalate esters were measured using high-performance liquid chromatography (HPLC). Using data collected from questionnaires and clinical examinations, the correlation between phthalate exposure and semen quality was analyzed.
RESULTS: The cumulative levels of the measured phthalate esters were significantly higher in the infertility group compared to the control group (P<0·05). Concentrations of the five phthalate esters in men varied by age with older men showing higher cumulative levels.
CONCLUSIONS: The presence of phthalates may contribute to male infertility in our study population.

Keywords

High-performance liquid chromatography Male infertility, Phthalates, Semen,

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Grants

  1. /British Heart Foundation
  2. /Medical Research Council
  3. /Biotechnology and Biological Sciences Research Council
  4. /Cancer Research UK
  5. /Howard Hughes Medical Institute
  6. /Wellcome Trust

MeSH Term

Adult
China
Chromatography, High Pressure Liquid
Environmental Exposure
Environmental Pollutants
Humans
Infertility, Male
Male
Middle Aged
Phthalic Acids
Semen
Semen Analysis
Young Adult

Chemicals

Environmental Pollutants
Phthalic Acids
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Word Cloud

Created with Highcharts 10.0.0phthalatesemeninfertilitymenlevelsestersPhthalatesUsinginfertilepresencefivemeasuredliquidchromatographycumulativehighergroupOBJECTIVES:environmentalchemicalsreproductivetoxicityestrogeniceffectsanimalsincreasingconcernhumanhealthAIM:determinewhetherassociatedMETHODS:samples10794fertilequantityusinghigh-performanceHPLCdatacollectedquestionnairesclinicalexaminationscorrelationexposurequalityanalyzedRESULTS:significantlycomparedcontrolP<0·05ConcentrationsvariedageoldershowingCONCLUSIONS:phthalatesmaycontributemalestudypopulationAnalysisPAEsHigh-performanceMaleSemen

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