Radiobiological treatment planning evaluation of inverse planning simulated annealing for cervical cancer high-dose-rate brachytherapy.
Tomas Palmqvist, Lucílio Dos S Matias, Anne B L Marthinsen, Marit Sundset, Anne D Wanderås, Signe Danielsen, Iuliana Toma-Dasu
Author Information
Tomas Palmqvist: Department of Medical Physics, Karolinska University Hospital, Stockholm, Sweden.
Lucílio Dos S Matias: Medical Radiation Physics, Department of Physics, Stockholm University, Stockholm, Sweden Department of Physics, Eduardo Mondlane University, Maputo, Mozambique Lucilio.Matias@ki.se.
Anne B L Marthinsen: Clinic of Oncology, St. Olav's Hospital, Trondheim, Norway.
Marit Sundset: Women's Clinic, St. Olav's Hospital, Trondheim, Norway.
Anne D Wanderås: Clinic of Oncology, St. Olav's Hospital, Trondheim, Norway.
Signe Danielsen: Clinic of Oncology, St. Olav's Hospital, Trondheim, Norway.
Iuliana Toma-Dasu: Medical Radiation Physics, Department of Physics, Stockholm University, Stockholm, Sweden.
AIM: To compare five inverse treatment plans with one conventional manually-optimized plan for cervical cancer brachytherapy (BT) using radiobiological parameters combined with dosimetric and volumetric parameters. MATERIALS AND METHODS: Five inverse treatment plans were calculated using an inverse planning simulated annealing (IPSA) algorithm for each of four fractions for 12 cervical cancerpatients treated with high-dose-rate (HDR) brachytherapy. The inverse treatment plans were compared to a manually-optimized plan used for the actual treatment of the patients. The comparison of the plans was performed with respect to the probability of cure without complication (P+). RESULTS: Overall, the manually optimized plan scored the best results; however, the probability of cure without complication is within an acceptable clinical range for all the plans. CONCLUSION: Although there are still considerable uncertainties in the radiobiological parameters, the radiobiological plan evaluation method presents itself as a potential complement to physical dosimetric methods.
