Escaping the Hemoglobin A1c-Centric World in Evaluating Diabetes Mellitus Interventions.

Robert A Vigersky
Author Information
  1. Robert A Vigersky: Diabetes Institute of the Walter Reed National Military Medical Center, Bethesda, MD, USA Robert.a.vigersky.mil@mail.mil.

Abstract

Any intervention in patients with diabetes must consider its effect on both the incidence of hypoglycemia and hemoglobin A1c. Yet, there is no single metric that expresses these key factors simultaneously. Such a composite metric would permit clinicians, regulators, manufacturers, payers, and researchers to more easily evaluate the merits of an intervention as well as enable the comparison of qualitatively different interventions. This article proposes a composite metric, the hypoglycemia-A1c score (HAS), as the basis for a more comprehensive approach for the stakeholders in diabetes treatment to better understand how an intervention affects diabetes management. The article also demonstrates how additional parameters such as effects on weight, quality of life, and costs could be included in such a scoring system.

Keywords

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MeSH Term

Blood Glucose
Blood Glucose Self-Monitoring
Diabetes Mellitus, Type 2
Glycated Hemoglobin
Humans
Hypoglycemic Agents
Insulin
Quality of Life

Chemicals

Blood Glucose
Glycated Hemoglobin A
Hypoglycemic Agents
Insulin

Word Cloud

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