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Current pathobiology reports
2015;3 (1): 37-45.

Systems Biology Approaches Applied to Regenerative Medicine.

Laura E McNamara, Lesley-Anne Turner, Karl V Burgess
Author Information
  1. Laura E McNamara: Centre for Cell Engineering, University of Glasgow, Glasgow, G12 8QQ UK.
  2. Lesley-Anne Turner: Centre for Cell Engineering, University of Glasgow, Glasgow, G12 8QQ UK.
  3. Karl V Burgess: Glasgow Polyomics, TCRC, University of Glasgow, Garscube Campus, Glasgow, G61 1QH UK.
PMID: 25722955 DOI: 10.1007/s40139-015-0072-4

Abstract

Systems biology is the creation of theoretical and mathematical models for the study of biological systems, as an engine for hypothesis generation and to provide context to experimental data. It is underpinned by the collection and analysis of complex datasets from different biological systems, including global gene, RNA, protein and metabolite profiles. Regenerative medicine seeks to replace or repair tissues with compromised function (for example, through injury, deficiency or pathology), in order to improve their functionality. In this paper, we will address the application of systems biology approaches to the study of regenerative medicine, with a particular focus on approaches to study modifications to the genome, transcripts and small RNAs, proteins and metabolites.

Keywords

Epigenomics Metabolomics Proteomics Regenerative medicine Systems biology Transcriptomics

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Created with Highcharts 10.0.0SystemsbiologystudysystemsRegenerativemedicinebiologicalapproachescreationtheoreticalmathematicalmodelsenginehypothesisgenerationprovidecontextexperimentaldataunderpinnedcollectionanalysiscomplexdatasetsdifferentincludingglobalgeneRNAproteinmetaboliteprofilesseeksreplacerepairtissuescompromisedfunctionexampleinjurydeficiencypathologyorderimprovefunctionalitypaperwilladdressapplicationregenerativeparticularfocusmodificationsgenometranscriptssmallRNAsproteinsmetabolitesBiologyApproachesAppliedMedicineEpigenomicsMetabolomicsProteomicsTranscriptomics

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