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Current opinion in virology
Jun, 2015;12 26-37.

Mechanisms of innate immune evasion in re-emerging RNA viruses.

Daphne Y Ma, Mehul S Suthar
Author Information
  1. Daphne Y Ma: Department of Pediatrics and Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30329, USA; Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA 30329, USA.
  2. Mehul S Suthar: Department of Pediatrics and Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30329, USA; Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA 30329, USA. Electronic address: msuthar@emory.edu.
PMID: 25765605 DOI: 10.1016/j.coviro.2015.02.005

Abstract

Recent outbreaks of Ebola, West Nile, Chikungunya, Middle Eastern Respiratory and other emerging/re-emerging RNA viruses continue to highlight the need to further understand the virus-host interactions that govern disease severity and infection outcome. As part of the early host antiviral defense, the innate immune system mediates pathogen recognition and initiation of potent antiviral programs that serve to limit virus replication, limit virus spread and activate adaptive immune responses. Concordantly, viral pathogens have evolved several strategies to counteract pathogen recognition and cell-intrinsic antiviral responses. In this review, we highlight the major mechanisms of innate immune evasion by emerging and re-emerging RNA viruses, focusing on pathogens that pose significant risk to public health.

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Grants

  1. R03AI109194/NIAID NIH HHS
  2. U19 AI083019/NIAID NIH HHS
  3. R56 AI110516/NIAID NIH HHS
  4. R03 AI109194/NIAID NIH HHS
  5. U19 AI057266/NIAID NIH HHS
  6. U19AI083019/NIAID NIH HHS
  7. 5U19AI057266/NIAID NIH HHS
  8. R56AI110516/NIAID NIH HHS

MeSH Term

Animals
Communicable Diseases, Emerging
Host-Pathogen Interactions
Humans
Immune Evasion
Immunity, Innate
Interferons
RNA Virus Infections
RNA Viruses
Receptors, Pattern Recognition
Signal Transduction
Virus Replication

Chemicals

Receptors, Pattern Recognition
Interferons
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 4

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