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Nature reviews. Genetics
Apr, 2015;16 (4): 224-36.

Evolutionary insights into host-pathogen interactions from mammalian sequence data.

Manuela Sironi, Rachele Cagliani, Diego Forni, Mario Clerici
Author Information
  1. Manuela Sironi: Bioinformatics, Scientific Institute IRCCS E. Medea, 23842 Bosisio Parini, Italy.
  2. Rachele Cagliani: Bioinformatics, Scientific Institute IRCCS E. Medea, 23842 Bosisio Parini, Italy.
  3. Diego Forni: Bioinformatics, Scientific Institute IRCCS E. Medea, 23842 Bosisio Parini, Italy.
  4. Mario Clerici: 1] Department of Physiopathology and Transplantation, University of Milan, 20090 Milan, Italy. [2] Don C. Gnocchi Foundation ONLUS, IRCCS, 20148 Milan, Italy.
PMID: 25783448 DOI: 10.1038/nrg3905

Abstract

Infections are one of the major selective pressures acting on humans, and host-pathogen interactions contribute to shaping the genetic diversity of both organisms. Evolutionary genomic studies take advantage of experiments that natural selection has been performing over millennia. In particular, inter-species comparative genomic analyses can highlight the genetic determinants of infection susceptibility or severity. Recent examples show how evolution-guided approaches can provide new insights into host-pathogen interactions, ultimately clarifying the basis of host range and explaining the emergence of different diseases. We describe the latest developments in comparative immunology and evolutionary genetics, showing their relevance for understanding the molecular determinants of infection susceptibility in mammals.

References

  1. Mol Biol Evol. 2005 Dec;22(12):2472-9 [PMID: 16107592]
  2. Mol Biol Evol. 2014 Nov;31(11):3040-56 [PMID: 25158795]
  3. Nat Rev Immunol. 2007 Dec;7(12):929-41 [PMID: 18037897]
  4. BMC Evol Biol. 2011 Dec 20;11:368 [PMID: 22185391]
  5. Nat Rev Immunol. 2013 Jan;13(1):34-45 [PMID: 23222502]
  6. Mol Cell. 2014 Apr 10;54(1):17-29 [PMID: 24657167]
  7. PLoS Biol. 2013;11(5):e1001571 [PMID: 23723737]
  8. Nature. 2010 Feb 11;463(7282):818-22 [PMID: 20081832]
  9. Nature. 2010 Jan 21;463(7279):349-52 [PMID: 20010607]
  10. J Immunol. 2005 Oct 1;175(7):4566-74 [PMID: 16177101]
  11. Viruses. 2012 Oct 23;4(10):2379-99 [PMID: 23202469]
  12. Nature. 2004 Feb 26;427(6977):848-53 [PMID: 14985764]
  13. Nat Rev Immunol. 2009 Jul;9(7):503-13 [PMID: 19498380]
  14. Nat Rev Immunol. 2011 Nov 11;11(12):823-36 [PMID: 22076556]
  15. Curr Biol. 2013 Jun 17;23(12):1085-8 [PMID: 23707426]
  16. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14040-5 [PMID: 16169905]
  17. Nature. 1996 Aug 29;382(6594):826-9 [PMID: 8752279]
  18. Annu Rev Biochem. 2007;76:295-329 [PMID: 17362200]
  19. PLoS Pathog. 2014 Mar 06;10(3):e1003968 [PMID: 24603659]
  20. Cell Host Microbe. 2012 Oct 18;12(4):598-604 [PMID: 23084925]
  21. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12957-62 [PMID: 15326304]
  22. BMC Evol Biol. 2013 Sep 12;13:194 [PMID: 24028551]
  23. PLoS Genet. 2008 Aug 01;4(8):e1000144 [PMID: 18670650]
  24. Virol J. 2013 Oct 10;10:304 [PMID: 24107353]
  25. Am J Hum Genet. 2012 Jun 8;90(6):973-85 [PMID: 22608500]
  26. Nature. 2013 Aug 8;500(7461):227-31 [PMID: 23831647]
  27. Nat Rev Immunol. 2013 Apr;13(4):280-93 [PMID: 23470320]
  28. Dev Comp Immunol. 2014 Jan;42(1):111-23 [PMID: 23764256]
  29. Mol Biol Evol. 2010 Oct;27(10):2257-67 [PMID: 20447933]
  30. Science. 2014 Dec 12;346(6215):1362-6 [PMID: 25504720]
  31. Curr Opin Genet Dev. 2014 Dec;29:31-8 [PMID: 25170983]
  32. J Virol. 2012 Jun;86(11):6350-3 [PMID: 22438550]
  33. PLoS Pathog. 2012;8(5):e1002666 [PMID: 22570610]
  34. Curr Opin Virol. 2011 Dec;1(6):649-57 [PMID: 22440923]
  35. Mol Biol Evol. 2013 Jun;30(6):1397-408 [PMID: 23505046]
  36. Nature. 2007 Dec 6;450(7171):870-3 [PMID: 18004303]
  37. Genetics. 2003 Jul;164(3):1229-36 [PMID: 12871927]
  38. Mol Biol Evol. 2007 Aug;24(8):1586-91 [PMID: 17483113]
  39. Mol Ecol. 2014 Jun;23(11):2783-96 [PMID: 24784171]
  40. Genome Biol Evol. 2014 Apr;6(4):830-45 [PMID: 24682156]
  41. Mol Biol Evol. 2013 Mar;30(3):642-53 [PMID: 23144040]
  42. Mol Biol Evol. 2005 Apr;22(4):1107-18 [PMID: 15689528]
  43. Nat Rev Microbiol. 2013 Oct;11(10):675-87 [PMID: 23979432]
  44. Proc Biol Sci. 2014 Dec 22;281(1797):null [PMID: 25355473]
  45. J Immunol. 2010 May 1;184(9):4973-81 [PMID: 20368272]
  46. Virus Res. 2006 Dec;122(1-2):144-53 [PMID: 16920215]
  47. J Virol. 2014 Aug;88(16):9220-32 [PMID: 24899185]
  48. Nature. 2013 Oct 24;502(7472):559-62 [PMID: 24048477]
  49. ACS Med Chem Lett. 2013 Feb 14;4(2):239-243 [PMID: 23526644]
  50. Science. 2007 Jun 22;316(5832):1756-8 [PMID: 17588933]
  51. Curr Opin Virol. 2012 Oct;2(5):561-8 [PMID: 22835485]
  52. Nat Rev Genet. 2014 Jun;15(6):379-93 [PMID: 24776769]
  53. Proc Biol Sci. 2014 Jan 15;281(1778):20133055 [PMID: 24430852]
  54. Mol Biol Evol. 2010 Sep;27(9):2172-86 [PMID: 20410160]
  55. J Exp Med. 2012 Oct 22;209(11):1969-83 [PMID: 23045604]
  56. Nature. 2012 Jul 26;487(7408):486-90 [PMID: 22810585]
  57. Mol Biol Evol. 2014 Sep;31(9):2402-14 [PMID: 24930137]
  58. Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2832-7 [PMID: 15689398]
  59. Genome Res. 2011 Jun;21(6):863-74 [PMID: 21393387]
  60. Nature. 2010 Mar 11;464(7286):275-8 [PMID: 20182425]
  61. Nat Commun. 2013;4:2212 [PMID: 23962925]
  62. Virology. 2014 Apr;454-455:291-8 [PMID: 24725956]
  63. Annu Rev Genet. 2012;46:677-700 [PMID: 23145935]
  64. Trends Ecol Evol. 2012 Nov;27(11):627-36 [PMID: 22901901]
  65. PLoS Pathog. 2012;8(10):e1002963 [PMID: 23071439]
  66. Virology. 2014 Nov;468-470:637-46 [PMID: 25310500]
  67. J Exp Med. 2005 May 16;201(10):1669-76 [PMID: 15897280]
  68. Mol Biol Evol. 2011 Nov;28(11):3033-43 [PMID: 21670087]
  69. Nature. 2011 Aug 24;477(7364):344-8 [PMID: 21866101]
  70. Nature. 2013 Mar 14;495(7440):251-4 [PMID: 23486063]
  71. Nature. 2013 Nov 28;503(7477):535-8 [PMID: 24172901]
  72. PLoS Genet. 2014 Mar 27;10 (3):e1004189 [PMID: 24675550]
  73. Mol Biol Evol. 2012 Apr;29(4):1125-39 [PMID: 22049066]
  74. Mol Biol Evol. 2011 Mar;28(3):1217-28 [PMID: 21087944]
  75. Emerg Infect Dis. 2013 May;19(5):736-42B [PMID: 23693015]
  76. PLoS Genet. 2011 Nov;7(11):e1002355 [PMID: 22072984]
  77. J Virol. 2012 May;86(9):5288-96 [PMID: 22379101]
  78. Mol Biol Evol. 2014 Feb;31(2):484-95 [PMID: 24132121]
  79. Science. 2013 Jan 25;339(6118):456-60 [PMID: 23258410]
  80. Science. 2003 Oct 10;302(5643):276-8 [PMID: 12958366]
  81. Nat Rev Genet. 2010 Jan;11(1):17-30 [PMID: 19953080]
  82. BMC Med. 2012 Nov 15;10:140 [PMID: 23153210]
  83. Mol Biol Evol. 2007 May;24(5):1219-28 [PMID: 17339634]
  84. PLoS Pathog. 2012;8(6):e1002676 [PMID: 22719245]
  85. Nat Rev Immunol. 2012 Oct;12(10):687-95 [PMID: 22976433]
  86. Genome Biol Evol. 2009 Jun 05;1:114-8 [PMID: 20333182]
  87. Curr Opin Immunol. 2014 Oct;30:9-16 [PMID: 24880709]
  88. J Mol Biol. 2011 Jan 28;405(4):1027-39 [PMID: 21112338]
  89. Science. 2009 Feb 6;323(5915):728-32 [PMID: 19197051]
  90. Viruses. 2012 Oct 25;4(11):2471-84 [PMID: 23202491]
  91. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7421-6 [PMID: 22532668]
  92. J Biol Chem. 2011 Jun 24;286(25):22235-42 [PMID: 21531728]
  93. PLoS Pathog. 2011 Dec;7(12):e1002439 [PMID: 22174692]
  94. Nature. 2008 Feb 21;451(7181):990-3 [PMID: 18288193]
  95. Trends Immunol. 2009 Mar;30(3):124-30 [PMID: 19211304]
  96. Nat Rev Immunol. 2013 Dec;13(12):851-61 [PMID: 24157573]
  97. Mol Biol Evol. 2002 Jun;19(6):950-8 [PMID: 12032251]
  98. Nat Genet. 2002 Dec;32(4):569-77 [PMID: 12457190]
  99. PLoS One. 2013;8(2):e56265 [PMID: 23441171]
  100. J Virol. 2000 Feb;74(3):1393-406 [PMID: 10627550]
  101. PLoS Genet. 2012;8(7):e1002764 [PMID: 22807683]
  102. Immunity. 2013 Jun 27;38(6):1129-41 [PMID: 23707475]
  103. Mol Biol Evol. 2013 Nov;30(11):2509-18 [PMID: 23904330]
  104. Cold Spring Harb Perspect Med. 2011 Sep;1(1):a006841 [PMID: 22229120]
  105. J Mol Biol. 2014 Mar 20;426(6):1351-65 [PMID: 24211720]
  106. Curr Opin Plant Biol. 2014 Apr;18:24-30 [PMID: 24491596]

MeSH Term

Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
Genetic Variation
Genomics
Host-Pathogen Interactions
Humans
Mammals
Molecular Sequence Data
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 28

Word Cloud

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