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Nature reviews. Molecular cell biology
May, 2015;16 (5): 269-80.

Multidimensional proteomics for cell biology.

Mark Larance, Angus I Lamond
Author Information
  1. Mark Larance: Laboratory for Quantitative Proteomics, Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  2. Angus I Lamond: Laboratory for Quantitative Proteomics, Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
PMID: 25857810 DOI: 10.1038/nrm3970

Abstract

The proteome is a dynamic system in which each protein has interconnected properties - dimensions - that together contribute to the phenotype of a cell. Measuring these properties has proved challenging owing to their diversity and dynamic nature. Advances in mass spectrometry-based proteomics now enable the measurement of multiple properties for thousands of proteins, including their abundance, isoform expression, turnover rate, subcellular localization, post-translational modifications and interactions. Complementing these experimental developments are new data analysis, integration and visualization tools as well as data-sharing resources. Together, these advances in the multidimensional analysis of the proteome are transforming our understanding of various cellular and physiological processes.

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Grants

  1. 073980/Wellcome Trust
  2. 097945/Wellcome Trust

MeSH Term

Animals
Cell Physiological Phenomena
Cytological Techniques
Databases, Protein
Humans
Mass Spectrometry
Organ Specificity
Protein Processing, Post-Translational
Proteins
Proteomics

Chemicals

Proteins
Journal Article Research Support, Non-U.S. Gov't Review
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