Do human tumor-associated viruses play a role in the development of synovial sarcoma?
Ulrich Lenze, Florian Pohlig, Heinrich Mühlhofer, Florian Lenze, Andreas Toepfer, Hans Rechl, Rainer Burgkart, Rüdiger von Eisenhart-Rothe, Melanie Straub
Author Information
Ulrich Lenze: Department for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Florian Pohlig: Department for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Heinrich Mühlhofer: Department for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Florian Lenze: Department for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Andreas Toepfer: Department for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Hans Rechl: Department for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Rainer Burgkart: Department for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Rüdiger von Eisenhart-Rothe: Department for Orthopedics and Orthopedic Sports Medicine, Klinikum rechts der Isar, Technical University, 81675 Munich, Germany.
Melanie Straub: Institute of Pathology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
BACKGROUND: To date, the pathomechanism of soft tissue sarcomas such as synovial sarcoma remains unclear whereas even a viral etiology was suspected. Aim of this study was to analyze whether EBV, HHV-8 or HPV play a role in the development of synovial sarcomas. FINDINGS: In total 41 synovial sarcomas were included in this retrospective study. For detection of EBV 1/2 and HHV-8, resection specimens were analyzed with regard to virus-specific sequences using a SingleStep PCR. HPV analysis was carried out by an HPV-specific multiplex-PCR and subsequent array-hybridization for HPV-typing. No virus-specific DNA of EBV, HHV-8 or HPV was detected. CONCLUSION: An involvement of these viruses in the etiology of synovial sarcoma was not detected but further studies are needed with different virus types and sarcoma entities.
