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Arthritis & rheumatology (Hoboken, N.J.)
Jul, 2015;67 (7): 1904-12.

Familial Risk of Sjögren's Syndrome and Co-aggregation of Autoimmune Diseases in Affected Families: A Nationwide Population Study.

Chang-Fu Kuo, Matthew J Grainge, Ana M Valdes, Lai-Chu See, Shue-Fen Luo, Kuang-Hui Yu, Weiya Zhang, Michael Doherty
Author Information
  1. Chang-Fu Kuo: University of Nottingham, Nottingham, UK, and Chang Gung Memorial Hospital, Taoyuan City, Taiwan.
  2. Matthew J Grainge: University of Nottingham, Nottingham, UK.
  3. Ana M Valdes: University of Nottingham, Nottingham, UK.
  4. Lai-Chu See: Chang Gung University, Taoyuan City, Taiwan.
  5. Shue-Fen Luo: Chang Gung Memorial Hospital, Taoyuan City, Taiwan.
  6. Kuang-Hui Yu: Chang Gung Memorial Hospital, Taoyuan City, Taiwan.
  7. Weiya Zhang: University of Nottingham, Nottingham, UK.
  8. Michael Doherty: University of Nottingham, Nottingham, UK.
PMID: 25940005 DOI: 10.1002/art.39127

Abstract

OBJECTIVE: To investigate familial aggregation of Sjögren's syndrome (SS) and the relative risks (RRs) of other autoimmune disease in relatives of patients with SS.
METHODS: We identified 23,658,577 beneficiaries enrolled in the Taiwan National Health Insurance system in 2010, of whom 12,754 had SS. We identified 21,009,551 parent-child relationships and 17,168,340 pairs of full siblings. The familial risks of SS and other autoimmune diseases, tetrachoric correlation, and familial transmission were estimated.
RESULTS: We identified 105 patients with SS who had an affected first-degree relative. The RR of SS was 18.99 (95% confidence interval [95% CI] 9.76-36.93) in siblings of patients with SS, 11.31 (95% CI 8.34-15.33) in offspring, and 12.46 (95% CI 9.34-16.62) in parents. Tetrachoric correlation coefficients were 0.53 (95% CI 0.41-0.65) for cotwins of affected individuals and 0.21 (95% CI 0.16-0.26) for full siblings. The familial transmission (heritability plus shared environmental contribution) was 0.54 (95% CI 0.44-0.77). In first-degree relatives of patients with SS, the RRs were 2.95 (95% CI 2.33-3.73) for rheumatoid arthritis, 6.25 (95% CI 5.15-7.58) for systemic lupus erythematosus, 2.39 (95% CI 0.77-7.41) for systemic sclerosis, 0.71 (95% CI 0.10-5.07) for idiopathic inflammatory myopathy, 1.97 (95% CI 1.29-3.02) for type 1 diabetes mellitus, 3.38 (95% CI 1.26-9.05) for multiple sclerosis, 1.67 (95% CI 0.83-3.33) for myasthenia gravis, 1.25 (95% CI 1.04-1.50) for psoriasis, 1.21 (95% CI 0.39-3.76) for inflammatory bowel disease, and 2.29 (95% CI 1.19-4.40) for vasculitis.
CONCLUSION: The risk of SS and other autoimmune diseases is increased in relatives of patients with SS, and more than one-half of phenotypic variance in SS can be explained by familial factors.

References

  1. Arthritis Rheum. 1993 Mar;36(3):340-7 [PMID: 8452579]
  2. J Rheumatol. 2001 Aug;28(8):1932-4 [PMID: 11508606]
  3. N Engl J Med. 2008 Feb 28;358(9):900-9 [PMID: 18204098]
  4. Lancet. 2005 Jul 23-29;366(9482):321-31 [PMID: 16039337]
  5. Ann Hum Genet. 1967 Aug;31(1):1-20 [PMID: 6056557]
  6. Am J Med. 1983 Jun;74(6):1066-71 [PMID: 6859056]
  7. Eur J Pediatr. 1991 Jul;150(9):652-5 [PMID: 1915519]
  8. Medicine (Baltimore). 2000 Jul;79(4):241-9 [PMID: 10941353]
  9. J Autoimmun. 2012 Aug;39(1-2):4-8 [PMID: 22326205]
  10. J Rheumatol. 1983 Jun;10(3):485-8 [PMID: 6887174]
  11. Ann Rheum Dis. 2015 Mar;74(3):e25 [PMID: 25381229]
  12. Nat Genet. 2013 Nov;45(11):1361-5 [PMID: 24097066]
  13. J Rheumatol. 2000 Sep;27(9):2264-6 [PMID: 10990245]
  14. Rheumatology (Oxford). 2000 Mar;39(3):267-73 [PMID: 10788534]
  15. J Rheumatol. 1999 Jul;26(7):1495-9 [PMID: 10405936]
  16. Stat Med. 1994 Nov 15;13(21):2233-47 [PMID: 7846422]
  17. Ann Rheum Dis. 2002 Jun;61(6):554-8 [PMID: 12006334]
  18. J Clin Pathol. 1971 Nov;24(8):732-5 [PMID: 5316137]
  19. Lancet. 2009 Jan 17;373(9659):234-9 [PMID: 19150704]
  20. Arthritis Rheum. 2007 Dec;56(12):3989-94 [PMID: 18050197]
  21. Autoimmun Rev. 2012 Feb;11(4):281-7 [PMID: 22001416]
  22. Pediatrics. 1973 May;51(5):943-5 [PMID: 4703408]
  23. Am J Med. 1976 Feb;60(2):286-92 [PMID: 766625]
  24. Am J Clin Pathol. 1987 Jul;88(1):26-31 [PMID: 3604987]
  25. Ann Hum Genet. 1979 Jan;42(3):371-90 [PMID: 434779]
  26. Br J Rheumatol. 1989 Dec;28(6):518-20 [PMID: 2590806]
  27. Eur J Hum Genet. 2010 Sep;18(9):1039-43 [PMID: 19826454]
  28. Ann Intern Med. 1984 Dec;101(6):748-56 [PMID: 6437309]
  29. Lupus. 2008 Nov;17(11):1004-9 [PMID: 18852224]
  30. Arthritis Rheum. 2005 Apr;52(4):1138-47 [PMID: 15818688]
  31. Genes Immun. 2009 Jan;10(1):68-76 [PMID: 19092842]
  32. Nat Genet. 2006 Jun;38(6):617-9 [PMID: 16699517]
  33. Ann Rheum Dis. 2015 Feb;74(2):369-74 [PMID: 24265412]
  34. Semin Arthritis Rheum. 2013 Dec;43(3):381-6 [PMID: 23916348]
  35. Ann Hum Genet. 1972 Nov;36(2):163-84 [PMID: 4676360]
  36. Nat Genet. 2013 Nov;45(11):1284-92 [PMID: 24097067]
  37. Immunity. 2011 Apr 22;34(4):602-15 [PMID: 21511186]
  38. Neurology. 2001 Oct 23;57(8):1359-63 [PMID: 11673571]
  39. Clin Exp Rheumatol. 2007 May-Jun;25(3):378-84 [PMID: 17631733]
  40. Br J Ind Med. 1993 Sep;50(9):861-2 [PMID: 8398881]
  41. J Infect Dis. 1991 Jul;164(1):22-8 [PMID: 1647426]
  42. Cell. 1996 May 3;85(3):311-8 [PMID: 8616887]
  43. J Rheumatol. 2005 Aug;32(8):1603-6 [PMID: 16078341]
  44. Lupus. 1997;6(4):395-8 [PMID: 9175026]
  45. Autoimmun Rev. 2014 Jul;13(7):756-61 [PMID: 24657515]
  46. Am J Hum Genet. 1990 Feb;46(2):222-8 [PMID: 2301392]
  47. Nat Genet. 2010 Jun;42(6):508-14 [PMID: 20453842]
  48. J Rheumatol. 1994 Feb;21(2):302-6 [PMID: 8182641]

MeSH Term

Adolescent
Adult
Arthritis, Rheumatoid
Autoimmune Diseases
Comorbidity
Diabetes Mellitus, Type 1
Family
Female
Genetic Predisposition to Disease
Humans
Lupus Erythematosus, Systemic
Male
Middle Aged
Multiple Sclerosis
Myasthenia Gravis
Myositis
Retrospective Studies
Risk Factors
Scleroderma, Systemic
Sjogren's Syndrome
Taiwan
Young Adult
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 9

Word Cloud

Created with Highcharts 10.0.095%CISS01familialpatients2autoimmunerelativesidentified21siblingsSjögren'srelativerisksRRsdisease12fulldiseasescorrelationtransmissionaffectedfirst-degree93325systemicsclerosisinflammatoryOBJECTIVE:investigateaggregationsyndromeMETHODS:23658577beneficiariesenrolledTaiwanNationalHealthInsurancesystem2010754009551parent-childrelationships17168340pairstetrachoricestimatedRESULTS:105RR1899confidenceinterval[95%CI]76-36931131834-15offspring4634-1662parentsTetrachoriccoefficients5341-065cotwinsindividuals16-026heritabilityplussharedenvironmentalcontribution5444-0779533-373rheumatoidarthritis6515-758lupuserythematosus3977-7417110-507idiopathicmyopathy9729-302typediabetesmellitus33826-905multiple6783-3myastheniagravis04-150psoriasis39-376bowel2919-440vasculitisCONCLUSION:riskincreasedone-halfphenotypicvariancecanexplainedfactorsFamilialRiskSyndromeCo-aggregationAutoimmuneDiseasesAffectedFamilies:NationwidePopulationStudy

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