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Cell metabolism
May 05, 2015;21 (5): 658-9.

Adult stem-like cells exclude "older" mitochondria.

Michael A Teitell
Author Information
  1. Michael A Teitell: Departments of Pathology and Laboratory Medicine, Pediatrics, and Bioengineering, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Broad Stem Cell Research Center, and California NanoSystems Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: mteitell@ucla.edu.
PMID: 25955200 DOI: 10.1016/j.cmet.2015.04.023

Abstract

Asymmetric distribution of damaged cellular constituents may occur during mitosis, resulting in more and less pristine daughter cell pairs. In Science, Katajisto et al., (2015) report that mammary stem-like cells (SLCs) unequally apportion older mitochondria to post-division daughter cells, with the daughter containing younger mitochondria maintaining the SLC pool.

References

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Grants

  1. CA156674/NCI NIH HHS
  2. CA90571/NCI NIH HHS
  3. GM114188/NIGMS NIH HHS
  4. R01 CA185189/NCI NIH HHS
  5. R01 CA107300/NCI NIH HHS
  6. R01 CA090571/NCI NIH HHS
  7. CA185189/NCI NIH HHS
  8. R01 GM073981/NIGMS NIH HHS
  9. GM073981/NIGMS NIH HHS
  10. R01 CA156674/NCI NIH HHS
  11. R01 GM114188/NIGMS NIH HHS

MeSH Term

Cell Division
Cellular Senescence
Humans
Mitochondria
Stem Cells
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Comment
Article has an altmetric score of 9

Word Cloud

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