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Alzheimer's & dementia (Amsterdam, Netherlands)
Jun 01, 2015;1 (2): 152-159.

Low eGFR is associated with dysexecutive and amnestic mild cognitive impairment.

Andrea R Zammit, Mindy J Katz, Molly E Zimmerman, Markus Bitzer, Richard B Lipton
Author Information
  1. Andrea R Zammit: Saul B. Korey Department of Neurology Albert Einstein College of Medicine, NY ; Einstein Aging Study Albert Einstein College of Medicine, NY.
  2. Mindy J Katz: Saul B. Korey Department of Neurology Albert Einstein College of Medicine, NY ; Einstein Aging Study Albert Einstein College of Medicine, NY.
  3. Molly E Zimmerman: Saul B. Korey Department of Neurology Albert Einstein College of Medicine, NY ; Einstein Aging Study Albert Einstein College of Medicine, NY.
  4. Markus Bitzer: Department of Internal Medicine, University of Michigan, MI.
  5. Richard B Lipton: Saul B. Korey Department of Neurology Albert Einstein College of Medicine, NY ; Einstein Aging Study Albert Einstein College of Medicine, NY ; Department of Epidemiology and Population Health Albert Einstein College of Medicine, NY.
PMID: 26005710 DOI: 10.1016/j.dadm.2014.12.002

Abstract

BACKGROUND: Few studies have explored the association between renal function and major subtypes of mild cognitive impairment (MCI).
METHODS: The sample was from the Einstein Aging Study. The estimated glomerular filtration rate (eGFR, calculated in mL/min/1.73m2 units) was classified into low (<45), moderate (45-59) and high (≥60). Separate binary logistic regression models were run to determine if eGFR is associated withamnestic MCI (aMCI) and dysexecutive MCI (dMCI).
RESULTS: Out of 622 eligible participants 65 (10.5%) had low eGFR, 43 (7.1%) had aMCI, and 46 (7.6) had dMCI. Low eGFR was independently associated with dMCI and aMCI in fully adjusted models.
CONCLUSION: At cross-section low eGFR is associated with a higher risk of both dMCI and aMCI. eGFR may contribute to the development of these cognitive states directly. Alternatively, low eGFR may be a marker for risk factors that influence both the kidney and the brain, such as coronary microvascular disease.

Keywords

amnestic MCI dysexecutive MCI renal function

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Grants

  1. P01 AG003949/NIA NIH HHS
  2. UL1 TR001073/NCATS NIH HHS
Journal Article
Article has an altmetric score of 7

Word Cloud

Created with Highcharts 10.0.0eGFRMCIlowassociatedaMCIdMCIcognitivedysexecutiverenalfunctionmildimpairmentmodels7LowriskmayamnesticBACKGROUND:studiesexploredassociationmajorsubtypesMETHODS:sampleEinsteinAgingStudyestimatedglomerularfiltrationratecalculatedmL/min/173m2unitsclassified<45moderate45-59high≥60SeparatebinarylogisticregressionrundeterminewithamnesticRESULTS:622eligibleparticipants65105%431%466independentlyfullyadjustedCONCLUSION:cross-sectionhighercontributedevelopmentstatesdirectlyAlternativelymarkerfactorsinfluencekidneybraincoronarymicrovasculardisease

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