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2015;2015 640263.

Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma.

Hang Yang, Wen-Qi Jiang, Ye Cao, Yong-An Sun, Jing Wei, Xin An, Ying-Chun Zhang, Ming Song, Shu-Sen Wang, Zhong-Yu Yuan, Rou-Jun Peng, Tan-Huan Chen, Li-Ren Li, Yan-Xia Shi
Author Information
  1. Hang Yang: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
  2. Wen-Qi Jiang: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
  3. Ye Cao: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Clinical Trial Center, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
  4. Yong-An Sun: Department of Neurology, Peking University First Hospital, Beijing 100034, China.
  5. Jing Wei: Department of Medical Oncology, Guangxi Traditional Chinese Medical University, Ruikang Hospital, Nanning 530011, China.
  6. Xin An: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
  7. Ying-Chun Zhang: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
  8. Ming Song: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
  9. Shu-Sen Wang: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
  10. Zhong-Yu Yuan: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
  11. Rou-Jun Peng: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
  12. Tan-Huan Chen: Department of Oncology, Huizhou Municipal Central Hospital, Huizhou 516001, China.
  13. Li-Ren Li: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Colorectal Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
  14. Yan-Xia Shi: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
PMID: 26063961 DOI: 10.1155/2015/640263

Abstract

AIM: Data from The Cancer Genome Atlas (TCGA) show that the ZNF703 gene amplifies and overexpresses in head and neck squamous cell carcinomas (HNSCC). However, the clinical relevance of this observation in HNSCC is unclear. The purpose of this study was to clarify the expression of ZNF703 protein and its prognostic effect on HNSCC.
METHODS: Two hundred ten HNSCC patients from Sun Yat-Sen University Cancer Center with complete survival follow-up were included in this study. Tumor samples from primary sites were collected. The expression of the ZNF703 protein was tested by immunohistochemistry (IHC).
RESULTS: The high expression of ZNF703 in HNSCC tumor tissues was significantly higher than that of the matched noncancerous tissues (48.6% versus 11.6%, P < 0.001). ZNF703 overexpression was correlated with tumor position (laryngeal carcinoma) and recurrence (all P < 0.05). Multivariate analysis revealed that ZNF703 protein overexpression was an independent prognostic factor (P = 0.022, hazard ratio = 1.635, 95% CI 1.073-2.493) in HNSCC patients.
CONCLUSION: ZNF703 overexpression is associated with adverse prognosis in HNSCC, which might be a novel biomarker of HNSCC.

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MeSH Term

Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell
Carrier Proteins
Female
Head and Neck Neoplasms
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Prognosis
Survival Analysis
Up-Regulation

Chemicals

Carrier Proteins
ZNF703 protein, human
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0ZNF703HNSCCexpressionproteinP0overexpressionCancerstudyprognosticpatientstumortissues6%<=1AIM:DataGenomeAtlasTCGAshowgeneamplifiesoverexpressesheadnecksquamouscellcarcinomasHoweverclinicalrelevanceobservationunclearpurposeclarifyeffectMETHODS:TwohundredtenSunYat-SenUniversityCentercompletesurvivalfollow-upincludedTumorsamplesprimarysitescollectedtestedimmunohistochemistryIHCRESULTS:highsignificantlyhighermatchednoncancerous48versus11001correlatedpositionlaryngealcarcinomarecurrence05Multivariateanalysisrevealedindependentfactor022hazardratio63595%CI073-2493CONCLUSION:associatedadverseprognosismightnovelbiomarkerElevatedProteinExpressionIndependentUnfavorablePrognosticFactorSurvivalPatientsHeadNeckSquamousCellCarcinoma

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