Humanized mouse models of human cytomegalovirus infection.
Lindsey B Crawford, Daniel N Streblow, Morgan Hakki, Jay A Nelson, Patrizia Caposio
Author Information
Lindsey B Crawford: VGTI, OHSU West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA.
Daniel N Streblow: VGTI, OHSU West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA.
Morgan Hakki: Division of Infectious Diseases, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
Jay A Nelson: VGTI, OHSU West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA.
Patrizia Caposio: VGTI, OHSU West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA. Electronic address: caposiop@ohsu.edu.
The generation of humanized mouse models in which immune deficient mice are engrafted with human tissues allows for the direct in vivo investigation of human-restricted viruses. These humanized mouse models have been developed and improved over the past 30 years. It is now possible to achieve high levels of human cell engraftment producing human myeloid and lymphoid lineage cells. Humanized mouse models have been increasingly utilized in the study of human cytomegalovirus (HCMV), a human-specific beta-herpesvirus that infects myeloprogenitor cells and establishes a life-long latency in the infected host. This review focuses on the strengths and limitations of the current humanized mouse models used to study HCMV replication, pathogenesis and treatment.
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R01 AI021640/NIAID NIH HHS
R37 AI021640/NIAID NIH HHS
AI21640/NIAID NIH HHS
Animals
Cytomegalovirus
Cytomegalovirus Infections
Disease Models, Animal
Humans
Mice
