Copula based flexible modeling of associations between clustered event times.

Candida Geerdens, Gerda Claeskens, Paul Janssen
Author Information
  1. Candida Geerdens: Center for Statistics, I-BioStat, Universiteit Hasselt, Agoralaan 1, 3590, Diepenbeek, Belgium.
  2. Gerda Claeskens: ORSTAT and Leuven Statistics Research Center, KU Leuven, Naamsestraat 69, 3000, Leuven, Belgium. Gerda.Claeskens@kuleuven.be.
  3. Paul Janssen: Center for Statistics, I-BioStat, Universiteit Hasselt, Agoralaan 1, 3590, Diepenbeek, Belgium.

Abstract

Multivariate survival data are characterized by the presence of correlation between event times within the same cluster. First, we build multi-dimensional copulas with flexible and possibly symmetric dependence structures for such data. In particular, clustered right-censored survival data are modeled using mixtures of max-infinitely divisible bivariate copulas. Second, these copulas are fit by a likelihood approach where the vast amount of copula derivatives present in the likelihood is approximated by finite differences. Third, we formulate conditions for clustered right-censored survival data under which an information criterion for model selection is either weakly consistent or consistent. Several of the familiar selection criteria are included. A set of four-dimensional data on time-to-mastitis is used to demonstrate the developed methodology.

Keywords

References

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MeSH Term

Female
Humans
Likelihood Functions
Mastitis
Models, Statistical

Word Cloud

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