Rui-Na Yang: Departments of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
Xin-Shuai Wang: Departments of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
Jing Ren: Departments of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
Yan-Fei Xie: Departments of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
Dan Zhou: Departments of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
Dong-Feng Ge: Departments of Pathology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
Xiao-Shan Feng: Departments of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
She-Gan Gao: Departments of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, P. R. China.
BACKGROUND: The ameloblastoma is the most common odontogenic epithelial tumor, which belong to benign neoplasms that present a painless course, and usually occur in the oromaxillo-facial region. Although the histopathological manifestation of ameloblastoma is benign, it has unique biological behavior, for example local invasion and recurrence repeatedly. A few case of ameloblastoma was locally aggressive growth, and rarely metastasis to other tissue, for example the lungs, lymph nodes, and spine. CASE REPORT: A 64-year-old Chinese man, diagnosed with metastatic ameloblastoma, was treated with palliative chemotherapy consisting of cyclophosphamide, doxorubicin, and cisplatin for six cycles, and radiotherapy for 50 Gy after the last cycle chemotherapy. During the surveillance CT scan after the therapy, the tissues of the tumor were nearly complete response. CONCLUSION: The purpose of this study was to report a case of a patient with a right mandible ameloblastoma that recurred repeatedly and metastasized into bilateral lung. After the chemotherapy and radiotherapy, the tissues of the tumor were nearly complete response. This case is interesting because it investigated the diagnosis and treatment of the malignancy ameloblastoma, as this may help diagnose and treatment for clinician to the metastatic ameloblastoma.
