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Genome biology
Aug 21, 2015;16 172.

Single-cell ATAC-seq: strength in numbers.

Sebastian Pott, Jason D Lieb
Author Information
  1. Sebastian Pott: Department of Human Genetics, The University of Chicago, 920 E. 58th Street, Chicago, IL, 60637, USA. spott@uchicago.edu.
  2. Jason D Lieb: Department of Human Genetics, The University of Chicago, 920 E. 58th Street, Chicago, IL, 60637, USA. jdlieb@uchicago.edu.
PMID: 26294014 DOI: 10.1186/s13059-015-0737-7

Abstract

Single-cell ATAC-seq detects open chromatin in individual cells. Currently data are sparse, but combining information from many single cells can identify determinants of cell-to-cell chromatin variation.

References

  1. Science. 2015 May 22;348(6237):910-4 [PMID: 25953818]
  2. Nat Methods. 2013 Dec;10(12):1213-8 [PMID: 24097267]
  3. Nature. 2012 Sep 6;489(7414):75-82 [PMID: 22955617]
  4. Nature. 2015 Jul 23;523(7561):486-90 [PMID: 26083756]
  5. Cell. 2015 May 21;161(5):1202-14 [PMID: 26000488]

MeSH Term

Animals
Cells
Chromatin
Epigenesis, Genetic
Epigenomics
Humans
Single-Cell Analysis

Chemicals

Chromatin
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