Matthew D Figley: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: figley@stanford.edu.
Aaron D Gitler: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: agitler@stanford.edu.
TDP-43 is a key disease protein for amyotrophic lateral sclerosis but how it drives motor neuron degeneration remains unresolved. A new study has modeled TDP-43 age-dependent axonal death in the Drosophila leg and used a powerful forward genetic screen to identify three novel suppressor genes.
