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Brain and language
Oct, 2016;161 45-56.

White matter integrity of cerebellar-cortical tracts in reading impaired children: A probabilistic tractography study.

Vindia G Fernandez, Jenifer Juranek, Anna Romanowska-Pawliczek, Karla Stuebing, Victoria J Williams, Jack M Fletcher
Author Information
  1. Vindia G Fernandez: University of Houston, 4811 Calhoun Rd., 3rd Floor, Houston, TX 77204-6022, United States. Electronic address: vgfernandez@uh.edu.
  2. Jenifer Juranek: University of Texas Health Science Center, 6655 Travis, Houston, TX 77030-1312, United States. Electronic address: jenifer.juranek@uth.tmc.edu.
  3. Anna Romanowska-Pawliczek: University of Texas Health Science Center, 6655 Travis, Houston, TX 77030-1312, United States. Electronic address: anna.m.pawliczek@uth.tmc.edu.
  4. Karla Stuebing: University of Houston, 4811 Calhoun Rd., 3rd Floor, Houston, TX 77204-6022, United States. Electronic address: karla.stuebing@times.uh.edu.
  5. Victoria J Williams: University of Houston, 4811 Calhoun Rd., 3rd Floor, Houston, TX 77204-6022, United States. Electronic address: tori85@gmail.com.
  6. Jack M Fletcher: University of Houston, 4811 Calhoun Rd., 3rd Floor, Houston, TX 77204-6022, United States. Electronic address: jack.fletcher@times.uh.edu.
PMID: 26307492 DOI: 10.1016/j.bandl.2015.07.006

Abstract

Little is known about the white matter integrity of cerebellar-cortical pathways in individuals with dyslexia. Building on previous findings of decreased volume in the anterior lobe of the cerebellum, we utilized novel cerebellar segmentation procedures and probabilistic tractography to examine tracts that connect the anterior lobe of the cerebellum and cortical regions typically associated with reading: the temporoparietal (TP), occipitotemporal (OT), and inferior frontal (IF) regions. The sample included 29 reading impaired children and 27 typical readers. We found greater fractional anisotropy (FA) for the poor readers in tracts connecting the cerebellum with TP and IF regions relative to typical readers. In the OT region, FA was greater for the older poor readers, but smaller for the younger ones. This study provides evidence for discrete, regionally-bound functions of the cerebellum and suggests that projections from the anterior cerebellum appear to have a regulatory effect on cortical pathways important for reading.

Keywords

Cerebellum Children DTI Dyslexia Reading Tractography

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Grants

  1. P50 HD052117/NICHD NIH HHS
  2. T32 MH096682/NIMH NIH HHS

MeSH Term

Adolescent
Anisotropy
Case-Control Studies
Cerebellum
Cerebral Cortex
Child
Diffusion Tensor Imaging
Dyslexia
Female
Humans
Male
Neural Pathways
Probability
Reading
White Matter
Journal Article

Word Cloud

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