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Critical reviews in oncogenesis
2015;20 (3-4): 227-43.

Pediatric Rhabdomyosarcoma.

Jack F Shern, Marielle E Yohe, Javed Khan
Author Information
  1. Jack F Shern: Genetics Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland; Pediatric Oncology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland.
  2. Marielle E Yohe: Genetics Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland; Pediatric Oncology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland.
  3. Javed Khan: Genetics Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland; Pediatric Oncology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland.
PMID: 26349418 DOI: 10.1615/critrevoncog.2015013800

Abstract

Rhabdomyosarcoma is the most common soft-tissue sarcoma of childhood, and despite clinical advances, subsets of these patients continue to suffer high levels of morbidity and mortality associated with their disease. Recent genetic and molecular characterization of these tumors using sophisticated genomics techniques, including next-generation sequencing experiments, has revealed multiple areas that can be exploited for new molecularly targeted therapies for this disease.

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Grants

  1. ZIA BC010998-09/Intramural NIH HHS

MeSH Term

Animals
Child
Epigenomics
Humans
Molecular Targeted Therapy
Rhabdomyosarcoma
Sarcoma
Journal Article Research Support, N.I.H., Intramural Review
Article has an altmetric score of 4

Word Cloud

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