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The Journal of nutrition
Nov, 2015;145 (11): 2535-41.

Urinary Phytoestrogens Are Associated with Subtle Indicators of Semen Quality among Male Partners of Couples Desiring Pregnancy.

Sunni L Mumford, Sungduk Kim, Zhen Chen, Dana Boyd Barr, Germaine M Buck Louis
Author Information
  1. Sunni L Mumford: Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Department of Health and Human Services, Bethesda, MD; and mumfords@mail.nih.gov.
  2. Sungduk Kim: Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Department of Health and Human Services, Bethesda, MD; and.
  3. Zhen Chen: Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Department of Health and Human Services, Bethesda, MD; and.
  4. Dana Boyd Barr: Rollins School of Public Health, Emory University, Atlanta, GA.
  5. Germaine M Buck Louis: Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Department of Health and Human Services, Bethesda, MD; and.
PMID: 26423741 DOI: 10.3945/jn.115.214973

Abstract

BACKGROUND: Phytoestrogens have been associated with subtle hormonal changes, although effects on male fecundity are largely unknown.
OBJECTIVE: We evaluated associations between male urinary phytoestrogen (isoflavone and lignan) concentrations and semen quality.
METHODS: This study was a prospective cohort study of 501 male partners of couples desiring pregnancy and discontinuing contraception. Each participant provided up to 2 semen samples that were analyzed for 35 semen quality endpoints the following day. Linear mixed-effects models were used to estimate associations between baseline urinary phytoestrogen concentrations and semen quality parameters, adjusted for age, body mass index (BMI), research site, and serum lipid and cotinine concentrations.
RESULTS: Most associations between urinary phytoestrogens and semen quality parameters were null. However, select individual phytoestrogens were associated with semen quality parameters, with associations dependent on the class of phytoestrogens and modified by BMI. Specifically, genistein and daidzein were associated with a lower percentage of normal sperm and increased abnormalities in semen morphology, with reduced associations observed as BMI increased (P < 0.05) [percentages (95% CIs) of normal morphology by WHO traditional criteria: genistein, main effect: -5.61% (-9.42%, -1.79%); interaction: 0.19% (0.06%, 0.31%) per log unit increase; daidzein, main effect: -5.35% (-9.36%, -1.34%); interaction: 0.18% (0.05%, 0.32%) per log unit increase]. Enterolactone was associated with fewer abnormalities in semen morphometry and morphology and decreased DNA fragmentation, with reduced associations observed as BMI increased (P < 0.05) [percentages (95% CIs) of abnormalities in the neck and midpiece: enterolactone, main effect: -3.35% (-6.51%, -0.19%); interaction: 0.11% (0.01%, 0.21%) per log unit increase].
CONCLUSIONS: These results suggest that male urinary phytoestrogen concentrations characteristic of the US population may be associated with subtle indicators of male fecundity and semen quality but were not associated with couple fecundity.

Keywords

isoflavones lignans male fertility phytoestrogens semen quality

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Grants

  1. N01-HD-3-3355/NICHD NIH HHS
  2. N01-HD-3-3356/NICHD NIH HHS
  3. N01-HD-3-3358/NICHD NIH HHS
  4. /Intramural NIH HHS

MeSH Term

4-Butyrolactone
Adult
Body Mass Index
Cholesterol
Cotinine
DNA Fragmentation
Endpoint Determination
Female
Fertility
Genistein
Humans
Isoflavones
Lignans
Linear Models
Male
Phytoestrogens
Pregnancy
Prospective Studies
Semen Analysis

Chemicals

Isoflavones
Lignans
Phytoestrogens
daidzein
Cholesterol
Genistein
Cotinine
4-Butyrolactone
2,3-bis(3'-hydroxybenzyl)butyrolactone
Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural
Article has an altmetric score of 22

Word Cloud

Created with Highcharts 10.0.00semenqualityassociatedmaleassociationsurinaryconcentrationsBMIphytoestrogensfecundityphytoestrogenparametersincreasedabnormalitiesmorphologymaineffect:interaction:perlogunitPhytoestrogenssubtlestudygenisteindaidzeinnormalreducedobservedP<05[percentages95%CIs-5-9-119%35%increase]BACKGROUND:hormonalchangesalthougheffectslargelyunknownOBJECTIVE:evaluatedisoflavonelignanMETHODS:prospectivecohort501partnerscouplesdesiringpregnancydiscontinuingcontraceptionparticipantprovided2samplesanalyzed35endpointsfollowingdayLinearmixed-effectsmodelsusedestimatebaselineadjustedagebodymassindexresearchsiteserumlipidcotinineRESULTS:nullHoweverselectindividualdependentclassmodifiedSpecificallylowerpercentagespermWHOtraditionalcriteria:61%42%79%06%31%increase36%34%18%05%32%EnterolactonefewermorphometrydecreasedDNAfragmentationneckmidpiece:enterolactone-3-651%-011%01%21%CONCLUSIONS:resultssuggestcharacteristicUSpopulationmayindicatorscoupleUrinaryAssociatedSubtleIndicatorsSemenQualityamongMalePartnersCouplesDesiringPregnancyisoflavoneslignansfertility

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