Preservation of Acquired Colistin Resistance in Gram-Negative Bacteria.

Ji-Young Lee, Myung-Jin Choi, Hyeon Jin Choi, Kwan Soo Ko
Author Information
  1. Ji-Young Lee: Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea.
  2. Myung-Jin Choi: Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea.
  3. Hyeon Jin Choi: Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea.
  4. Kwan Soo Ko: Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea ksko@skku.edu.

Abstract

Colistin-resistant mutants were obtained from 17 colistin-susceptible strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. The stability of colistin resistance in these mutants was investigated. Three of four colistin-resistant P. aeruginosa mutants recovered colistin susceptibility in colistin-free medium; however, colistin-susceptible revertants were obtained from only one strain each of A. baumannii and E. coli. No susceptible revertants were obtained from K. pneumoniae mutants.

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MeSH Term

Acinetobacter baumannii
Anti-Bacterial Agents
Bacterial Proteins
Colistin
Drug Resistance, Bacterial
Escherichia coli
Gene Expression
Klebsiella pneumoniae
Membrane Proteins
Microbial Sensitivity Tests
Mutation Rate
Pseudomonas aeruginosa
Transcription Factors

Chemicals

Anti-Bacterial Agents
Bacterial Proteins
Membrane Proteins
PhoQ protein, Bacteria
PmrB protein, bacteria
Transcription Factors
pmrA protein, Bacteria
PhoP protein, Bacteria
Colistin