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Autophagy
2015;11 (12): 2393-7.

The integration of autophagy and cellular trafficking pathways via RAB GAPs.

Andreas Kern, Ivan Dikic, Christian Behl
Author Information
  1. Andreas Kern: a Institute for Pathobiochemistry; University Medical Center of the Johannes Gutenberg University ; Mainz , Germany.
  2. Ivan Dikic: b Buchmann Institute for Molecular Life Sciences; Goethe University Frankfurt ; Frankfurt am Main , Germany.
  3. Christian Behl: a Institute for Pathobiochemistry; University Medical Center of the Johannes Gutenberg University ; Mainz , Germany.
PMID: 26565612 DOI: 10.1080/15548627.2015.1110668

Abstract

Macroautophagy is a conserved degradative pathway in which a double-membrane compartment sequesters cytoplasmic cargo and delivers the contents to lysosomes for degradation. Efficient formation and maturation of autophagic vesicles, so-called phagophores that are precursors to autophagosomes, and their subsequent trafficking to lysosomes relies on the activity of small RAB GTPases, which are essential factors of cellular vesicle transport systems. The activity of RAB GTPases is coordinated by upstream factors, which include guanine nucleotide exchange factors (RAB GEFs) and RAB GTPase activating proteins (RAB GAPs). A role in macroautophagy regulation for different TRE2-BUB2-CDC16 (TBC) domain-containing RAB GAPs has been established. Recently, however, a positive modulation of macroautophagy has also been demonstrated for the TBC domain-free RAB3GAP1/2, adding to the family of RAB GAPs that coordinate macroautophagy and additional cellular trafficking pathways.

Keywords

RAB GAP RAB GTPase RAB3GAP autophagosome formation autophagy vesicle trafficking

References

  1. J Biol Chem. 1997 Feb 21;272(8):4655-8 [PMID: 9030515]
  2. Dev Biol. 2013 Aug 15;380(2):274-85 [PMID: 23685254]
  3. J Biol Chem. 2008 Apr 4;283(14):9187-95 [PMID: 18258599]
  4. Diabetes. 2015 Jun;64(6):1914-22 [PMID: 25576050]
  5. J Biol Chem. 1998 Sep 18;273(38):24781-5 [PMID: 9733780]
  6. J Biol Chem. 2013 Jul 5;288(27):19548-57 [PMID: 23671284]
  7. EMBO J. 1999 Apr 1;18(7):1772-82 [PMID: 10202141]
  8. Neuron. 2011 Feb 24;69(4):749-62 [PMID: 21338884]
  9. Proc Natl Acad Sci U S A. 2012 May 1;109(18):6981-6 [PMID: 22509044]
  10. Physiol Rev. 2013 Jan;93(1):269-309 [PMID: 23303910]
  11. EMBO J. 2006 Jan 25;25(2):278-89 [PMID: 16395330]
  12. Curr Biol. 2010 Feb 9;20(3):198-208 [PMID: 20116244]
  13. Nat Cell Biol. 2014 Jun;16(6):495-501 [PMID: 24875736]
  14. Nat Rev Mol Cell Biol. 2012 Feb;13(2):67-73 [PMID: 22251903]
  15. Nat Rev Mol Cell Biol. 2009 Aug;10(8):513-25 [PMID: 19603039]
  16. Autophagy. 2014;10(12):2297-309 [PMID: 25495476]
  17. J Cell Biol. 2001 Apr 2;153(1):191-206 [PMID: 11285285]
  18. EMBO Rep. 2014 Apr;15(4):392-401 [PMID: 24603492]
  19. J Cell Biol. 2011 Mar 7;192(5):839-53 [PMID: 21383079]
  20. Curr Biol. 2012 Jan 10;22(1):R29-34 [PMID: 22240478]
  21. Mol Cell. 2012 Aug 24;47(4):535-46 [PMID: 22795129]
  22. APMIS. 2014 Nov;122(11):1080-7 [PMID: 24673604]
  23. Hum Mutat. 2013 May;34(5):686-96 [PMID: 23420520]
  24. Mol Cell Proteomics. 2012 Jun;11(6):M111.016444 [PMID: 22337587]
  25. J Cell Biol. 2007 Jul 30;178(3):363-9 [PMID: 17646400]
  26. Cell. 2013 Sep 12;154(6):1285-99 [PMID: 24034251]
  27. J Cell Biol. 2010 Apr 19;189(2):223-32 [PMID: 20404108]
  28. Diabetes. 2015 Jun;64(6):1901-3 [PMID: 25999533]
  29. Am J Physiol Renal Physiol. 2015 Nov 1;309(9):F779-90 [PMID: 26336159]
  30. Mol Biol Cell. 2014 Nov 15;25(23):3779-97 [PMID: 25232007]
  31. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7811-6 [PMID: 20375281]
  32. Circulation. 2015 Jan 27;131(4):390-400; discussion 400 [PMID: 25369805]
  33. Autophagy. 2014 Jul;10(7):1154-66 [PMID: 24915298]
  34. J Biol Chem. 2008 Jun 27;283(26):18323-30 [PMID: 18450757]
  35. J Cell Biol. 2014 Jun 9;205(5):707-20 [PMID: 24891604]
  36. Cell. 2010 May 14;141(4):564-6 [PMID: 20478247]
  37. J Cell Sci. 2009 Jul 15;122(Pt 14):2371-82 [PMID: 19531583]
  38. Nature. 2010 Jul 1;466(7302):68-76 [PMID: 20562859]
  39. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10029-34 [PMID: 16782817]
  40. J Cell Biol. 2012 May 28;197(5):659-75 [PMID: 22613832]
  41. Mol Cell Biol. 2012 May;32(9):1733-44 [PMID: 22354992]
  42. Curr Biol. 2014 Mar 17;24(6):609-20 [PMID: 24613307]
  43. Cell. 2008 Jan 11;132(1):27-42 [PMID: 18191218]
  44. Mol Cell Biol. 2015 Sep 1;35(17):3044-58 [PMID: 26100023]
  45. Biochem Soc Trans. 2014 Oct;42(5):1327-34 [PMID: 25233411]
  46. Dev Cell. 2013 Apr 15;25(1):15-28 [PMID: 23562278]
  47. J Cell Sci. 2012 Nov 1;125(Pt 21):5026-39 [PMID: 22854040]
  48. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15787-92 [PMID: 23019362]
  49. Science. 2000 Dec 1;290(5497):1717-21 [PMID: 11099404]
  50. EMBO J. 2010 Jun 2;29(11):1792-802 [PMID: 20418806]

Grants

  1. 250241/European Research Council

MeSH Term

Animals
Autophagy
GTPase-Activating Proteins
Guanine Nucleotide Exchange Factors
Humans
Lysosomes
Protein Transport
rab GTP-Binding Proteins

Chemicals

GTPase-Activating Proteins
Guanine Nucleotide Exchange Factors
rab GTP-Binding Proteins
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 4

Word Cloud

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