Genetic association of the ApoB and ApoA1 gene polymorphisms with the risk for alcohol-induced osteonecrosis of femoral head.
Yuan Wang, Yuju Cao, Yizhou Li, Yongchang Guo, Quanjian Wang, Min Yang, Ning Zhang, Tianbo Jin, Jianzhong Wang
Author Information
Yuan Wang: Inner Mongolia Medical University Hohhot 010010, Inner Mongolia, China.
Yuju Cao: Zhengzhou Traditional Chinese Medicine Traumatology Hospital Zhengzhou 450016, Henan, China.
Yizhou Li: Inner Mongolia Medical University Hohhot 010010, Inner Mongolia, China.
Yongchang Guo: Zhengzhou Traditional Chinese Medicine Traumatology Hospital Zhengzhou 450016, Henan, China.
Quanjian Wang: Zhengzhou Traditional Chinese Medicine Traumatology Hospital Zhengzhou 450016, Henan, China.
Min Yang: National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, Shaanxi, China.
Ning Zhang: National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, Shaanxi, China.
Tianbo Jin: National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, Shaanxi, China ; School of Life Sciences, Northwest University Xi'an 710069, Shaanxi, China.
Jianzhong Wang: Department of Orthopaedic Surgery, The Second Affiliated Hospital, Inner Mongolia Medical University Hohhot 010030, Inner Mongolia, China.
Polymorphisms of apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1) gene and ApoB/ApoA1 Ratio were associated with lipid metabolism disorders in previous reports. The aim of this study assess whether variation of ApoB, ApoA1 gene are associated or not with alcohol-induced osteonecrosis of femoral head (ONFH). In a case-control study, we genotyped 4 single-nucleotide polymorphisms (SNPs) in ApoB and ApoA1 genes in 209 alcohol-induced ONFH patients and 300 healthy control subjects in Han Chinese population using χ(2) test and genetic model analysis. The analysis revealed that the frequencies of ApoB and ApoA1 genotypes were significantly different in alcohol-induced ONFH patients than in controls. We identified rs1042034, rs676210 and rs673548 in ApoB gene were associated with decreased risk of alcohol-induced ONFH using recessive model analysis (odds ratio [OR], 0.44; 95% confidence interval [CI], 0.19-0.99; P = 0.042), the OR, CI, P value of three SNPs were the same after adjusted for gender + age. We also identified rs632153 in ApoA1 gene was associated with increased risk of alcohol-induced ONFH using allele model (OR, 1.83; 95% CI, 1.16-2.88; P = 0.008) and log-additive model (adjusted OR, 1.77; 95% CI, 1.00-3.14; P = 0.046), analysis respectively. Haplotype analysis demonstrated no difference between ApoB and alcohol-induced ONFH. Polymorphisms of the ApoB and ApoA1 gene are associated with alcohol-induced ONFH in the Han Chinese population.
